Over the last several years I have received hundreds of emails from males in regards to POIS. The number of publications about POIS in the scientific literature, as well as articles in the popular press have been steadily rising. While some medications such as finasteride and SSRI are known to cause POIS symptoms, the fact that the reports/rates of POIS have been steadily increasing suggest something else is also at play in this condition. Some people report relief after thyroid or testosterone therapy, suggesting the conditions is energetic in origin. The case study below is perhaps the most direct evidence that POIS is energetic in origin, considering its successful and sustained resolution with niacinamide therapy, at a daily dose of 500mg, taken for 5 months.
https://pubmed.ncbi.nlm.nih.gov/38952608/
“…Post-orgasmic illness syndrome (POIS) is a rare condition characterized by debilitating symptoms following ejaculation. We present a case of a 25-year-old male with flu-like symptoms post-ejaculation since age 17. Despite minimal relief from conventional treatments, a comprehensive evaluation led to the diagnosis of POIS and successful management with niacinamide therapy. The presentation of flu-like symptoms following ejaculation in this case raises several questions regarding the underlying pathophysiology. While the exact cause of his symptoms remains elusive, the resolution achieved with niacinamide therapy underscores the importance of considering alternative treatment modalities in complex cases. The role of varicocele in symptom manifestation, if any, also warrants consideration, as varicocele has been associated with male infertility and testicular dysfunction.”
“…Following the comprehensive evaluation, the patient was initiated on niacinamide therapy (500 mg per day, taken orally in the form of a tablet) for five months. Niacinamide, a form of vitamin B3, is known for its role in cellular energy production and overall metabolic function. Its mechanism of action in alleviating the post-ejaculation symptoms in this case remains an area of interest and warrants further exploration.”
