DHT restores anabolism / vitality / sexuality even in 90+ y.o. males

A great study, a true blast from the (better) past, when androgenic steroids and especially DHT were not considered the devil reincarnate, but were commonly used for all types of ailments, including the broad physiological and psychological symptoms of aging such as sarcopenia (muscle loss), osteoporosis, senility, apathy/depression, and even sexual function. The study demonstrates … Read more

Androgens (e.g. DHT) curative even for treatment-resistant breast cancer

As many of my readers know, back in the “good ol’ days” (when medicine was slightly less evil and berserk) breast cancer in women was treated with androgens, and the results were so impressive that a synthetic DHT-derivative known as Drostanolone / Masteron (2α-Methyl-DHT) was approved by the FDA in 1960s as the main therapy … Read more

Endotoxin (LPS) as a cause of systemic inflammation seen in obesity

Yet another study implicating the great villain of systemic health – endotoxin / LPS. It is well-known that most people with obesity have high levels of inflammatory biomarkers both in their tissues and bloodstream. The study below demonstrates that the inflammation seen in adipose tissue of obese organisms is likely due to endotoxin / LPS. … Read more

Endotoxin behind the mortality of Black Death and 1918 Flu pandemics

As many of my readers know, many/most people dying from COVID-19 develop either sepsis and/or respiratory failure. Endotoxin (LPS) is now a known cause behind both of these conditions, as a virus by itself has no known mechanism of causing a cytokine storm. As much as I revile the term “scientific consensus”, in this case … Read more

Sugar (sucrose) lowers stress-induced cortisol

Just a quick post to give some props to the much-vilified sucrose. The study below demonstrates that sucrose consumption for just 3 days prior, blunted most of the negative effects of stress, and especially the rise in plasma cortisol. The HED of sucrose was about 4g/kg, which matches closely Peat’s recommendations that consumption of 350g-400g … Read more

Some aromatase inhibitors (AI) are estrogenic

I have long suspected this considering the peculiar side effects of some AI drugs, but was not able to find concrete evidence…until now. The study below demonstrates that one of the most widely used AI – anastrozole – is a potent estrogen receptor activator/agonist, and at low concentrations too. At higher concentrations, the estrogenic effects … Read more

Even “non-carcinogenic” estrogens can cause cancer

I know, the title is a “paradox”, but this is truly what the article discusses. By now, we already know that the word “paradox” in science is just a euphemism for idotism and/or fraud. Apparently, mainstream medicine has managed to convinced the public somehow that there are carcinogenic and non-carcinogenic estrogens. An example of the … Read more