Glaucoma likely a metabolic disease, treatable by pyruvate and/or niacinamide

About a year ago, a publication came out that demonstrated therapeutic effects of raising the (mitochondrial) NAD/NADH ratio in glaucoma patients. That study used niacinamide (NAM) and suggested that the “irreversible” changes in eye structure seen in glaucoma patients are in fact nothing more than a downstream effect of metabolic (OXPHOS) disturbances. Now, a new … Read more Glaucoma likely a metabolic disease, treatable by pyruvate and/or niacinamide

Niacinamide may treat ALS by improving energetic state

Another study sent to me by the Austrian collaborator. Once again, the energetic origin of “incurable” diseases like amyotrophic lateral sclerosis (ALS) is on full display. The study elucidates that ALL types of ALS are characterized by metabolic/energetic abnormalities and the metabolic phenotype of that disease is indistinguishable from cancer. In other words, little to … Read more Niacinamide may treat ALS by improving energetic state

Niacinamide (vitamin B3) may cure HIV (human study)

The title of the post sounds a bit too good to be true but this is basically what the case study claims and is also reported by the mouthpiece of Big Pharma – the Science Magazine. So, little by little the truth comes out, which is always good news. The only bad news in this … Read more Niacinamide (vitamin B3) may cure HIV (human study)

Vitamin B3 may treat “incurable” muscle disease

Over the last 2-3 years I have seen a dramatic increase in the number of studies and popular press articles using the keywords “controversial”, “paradox”, “paradigm shift”, “ameliorates an incurable condition X”, etc. This is just a thinly veiled attempt to mask the collapse of the corrupt dogma that has controlled medicine for more than … Read more Vitamin B3 may treat “incurable” muscle disease

Raising NAD levels may be therapeutic for COVID-19

A rather timely study, which demonstrates once again the crucial role energy plays even in “non-metabolic” diseases such as viral infections. At this point, even mainstream medicine admits that every function of the organism requires energy, so it would be plausible to expect an organism with higher energy reserves to be better able to defend … Read more Raising NAD levels may be therapeutic for COVID-19

Vitamin B3 remarkably therapeutic for brain cancer (glioblastoma)

As many of my readers know, brain cancer rates have been steadily rising over the last 3 decades and are now a leading cause of death in both elderly and also very young people. The most common (and deadly) form of brain cancer is glioblastoma multiforme and the average life expectancy after diagnosis is just … Read more Vitamin B3 remarkably therapeutic for brain cancer (glioblastoma)

Niacinamide may treat fibrotic eye disease and prevent vision loss

A great new study that demonstrated nicotinamide (NAM) may also have anti-fibrotic effects in addition to its positive effects on maintaining favorable NAD/NADH ratio and redox balance. The mechanism of action of NAM was inhibition of the TGF-β pathway and overall reduction of inflammation. This anti-fibrotic effect of NAM may explain its well-known protective effects … Read more Niacinamide may treat fibrotic eye disease and prevent vision loss

Forcing the heart to burn glucose instead of fat may cure heart failure

One of the blockbuster studies I have seen over the last 12 months. It reads as if written by Peat himself and discusses tissue regeneration, Randle cycle, dietary control of metabolism, etc. AFAIK this is the first study brave enough to demonstrate that simply switching fuel types in an organism can have profound structural effects, … Read more Forcing the heart to burn glucose instead of fat may cure heart failure

Low-dose (but not high) niacinamide reverses reproductive decline in old females

A great new study, which once again confirms the importance of metabolism in “aging” disorders such as infertility (both female and male) and menopause. More specifically, it was the increase in NAD/NADH ratio that was the main mechanism of action behind the beneficial effects of nicotinamide mononucleotide (NMN) the study below discovered. Now, the study … Read more Low-dose (but not high) niacinamide reverses reproductive decline in old females

Dietary niacinamide (B3) deficiency may be a cause of schizophrenia

As many of my readers know, the link between niacinamide and schizophrenia dates back at least the 1950s and possibly much earlier. The late Abram Hoffer, one of the founders of the orthomolecular approach, was convinced that stress was a huge factor in mental illness and ran several successful trials with high dose niacin/niacinamide as … Read more Dietary niacinamide (B3) deficiency may be a cause of schizophrenia