Niacin / niacinamide ratio may be a very good test for bacterial infection

A very interesting study, which may provide a cheap, fast and easy method for testing whether a person has a bacterial or not. This is very useful in cases of respiratory diseases where a clinician has to determine if the respiratory infection is of bacterial or viral origin, in order to decide if prescribing antibiotics … Read more

Age-related steroid deficiency may be treatable with niacinamide

The study is actually about eye health, and the effects androgens play in it. However, the findings are not limited to the eyes and are in fact applicable for any other tissue/organ experiencing a decline in steroidogenesis with advancing age, which is basically all of them. As such, I am posting this study not so … Read more

Niacinamide may treat lymphoma

A very interesting study and a “synchronicity” event as well, considering the recent in-vivo experiments I conducted with a combination of vitamin B1 and vitamin B3 (niacinamide) in a mouse xenograft model of human mantle-cell lymphoma. In that experiment of mine, HED of 15mg/kg B1 and 30mg/kg B3 completely stopped the tumor growth. One of … Read more

Niacinamide + pyruvate may treat glaucoma (human study)

Some excellent results from a human clinical trial. Namely, a combination of 3g niacinamide and 3g (calcium) pyruvate daily demonstrated significant therapeutic effect in patients with already established glaucoma. I can’t access to actual study link on JAMA, but I suspect the mechanism of action is, again, improved bioenergetic state with niacinamide raising the NAD/NADH … Read more

Niacinamide increases aerobic capacity, muscle endurance in humans

There has been a steady increase in human studies with vitamin B3 analogs over the last 3-5 years. Most of that human research is sponsored by the company ChromaDex, which sells a proprietary formulation of nicotinamide riboside (NR), despite its own studies demonstrating that niacinamide / nicotinamide (NAM) is just as effective at raising NAD/NADH … Read more

Niacinamide improves glucose metabolism and muscle health in humans

Niacinamide probably does not need in introduction to the people reading my posts. However, despite the multitude of animal studies demonstrating beneficial effects of this vitamin in virtually every chronic condition (and especially conditions associated with disturbed glucose metabolism), human studies with it are very scarce. The study below is one of those rare human … Read more

Glucose + vitamin B3 combo synergistic for treating mitochondrial disease

A very interesting study, which demonstrates the unique synergy between glucose and vitamin B3 in treating deficiencies of function in Complex I & II of the electron transport chain (ETC). Deficiencies on those metabolic steps are the most common causes for the wide varieties of debilitating symptoms (or even death) in people with “inborn” mitochondrial … Read more

Niacinamide as treatment for scleroderma (systemic sclerosis)

Yet another “incurable” disease has been demonstrated to be nothing more but energetic deficiency in disguise. According to mainstream medicine, scleroderma (also known as systemic sclerosis) is an incurable chronic, autoimmune, progressive, fibrotic disease that attacks virtually all organs and can lead to significant disability and even death if it affects some of the more … Read more

Glaucoma likely a metabolic disease, treatable by pyruvate and/or niacinamide

About a year ago, a publication came out that demonstrated therapeutic effects of raising the (mitochondrial) NAD/NADH ratio in glaucoma patients. That study used niacinamide (NAM) and suggested that the “irreversible” changes in eye structure seen in glaucoma patients are in fact nothing more than a downstream effect of metabolic (OXPHOS) disturbances. Now, a new … Read more

Niacinamide may treat ALS by improving energetic state

Another study sent to me by the Austrian collaborator. Once again, the energetic origin of “incurable” diseases like amyotrophic lateral sclerosis (ALS) is on full display. The study elucidates that ALL types of ALS are characterized by metabolic/energetic abnormalities and the metabolic phenotype of that disease is indistinguishable from cancer. In other words, little to … Read more