To Extract Knowledge from Matter
Perceive, Think, Act
As many of my readers know, brain cancer rates have been steadily rising over the last 3 decades and are now a leading cause of death in both elderly and also very young people. The most common (and deadly) form of brain cancer is glioblastoma multiforme and the average life expectancy after diagnosis is just … Read more Vitamin B3 remarkably therapeutic for brain cancer (glioblastoma)
A great new study that demonstrated nicotinamide (NAM) may also have anti-fibrotic effects in addition to its positive effects on maintaining favorable NAD/NADH ratio and redox balance. The mechanism of action of NAM was inhibition of the TGF-β pathway and overall reduction of inflammation. This anti-fibrotic effect of NAM may explain its well-known protective effects … Read more Niacinamide may treat fibrotic eye disease and prevent vision loss
One of the blockbuster studies I have seen over the last 12 months. It reads as if written by Peat himself and discusses tissue regeneration, Randle cycle, dietary control of metabolism, etc. AFAIK this is the first study brave enough to demonstrate that simply switching fuel types in an organism can have profound structural effects, … Read more Forcing the heart to burn glucose instead of fat may cure heart failure
A great new study, which once again confirms the importance of metabolism in “aging” disorders such as infertility (both female and male) and menopause. More specifically, it was the increase in NAD/NADH ratio that was the main mechanism of action behind the beneficial effects of nicotinamide mononucleotide (NMN) the study below discovered. Now, the study … Read more Low-dose (but not high) niacinamide reverses reproductive decline in old females
As many of my readers know, the link between niacinamide and schizophrenia dates back at least the 1950s and possibly much earlier. The late Abram Hoffer, one of the founders of the orthomolecular approach, was convinced that stress was a huge factor in mental illness and ran several successful trials with high dose niacin/niacinamide as … Read more Dietary niacinamide (B3) deficiency may be a cause of schizophrenia
The evidence continues to pile on that naming the (in)famous observation made by Otto Warburg in regards to cancer an “effect” is one of the most profound falsehoods the medical profession has ever concocted. Almost a century after the Warburg “Effect” term was coined, the evidence rapidly accumulates that the lactic acidosis is not at … Read more Acidosis (Warburg Effect) drives cancer through increased fat oxidation (Randle Cycle)
The mainstream medical dogma is that after the onset of menopause, female reproductive potential is essentially zero. I posted a thread recently that challenged that dogma and demonstrated that infertility is essentially an energetic dysfunction process and can be reversed with exposure to red light. Fertility depends on metabollism (ATP), not age Now, the study … Read more Niacinamide may restore female fertility in old age
Just over a week ago I posted a thread on ALS being linked to increased fatty acid oxidation (FAO) and as such a decreased glucose availability/oxidation. http://haidut.me/?p=239 Now, the study below further corroborates this FAO-disease association by demonstrating a causative link between a change in the microbiome and the development/progression of ALS. The change in … Read more Niacinamide may improve symptoms of ALS
The study below demonstrates that vascular (and other soft tissue) calficiation depends on overpexression of the enzyme Poly (ADP-ribose) polymerase (PARP). Inhibiting the synthesis/activity of that enzyme prevented vascular calficiation, and as such can be a powerful prevention tool for CVD and in general any ischemic event. The study used minocycline (a tetracycline-family antibiotic) as … Read more Niacinamide, tetracyclines may prevent / reverse vascular calcification
As many of your have seen on TV, there is currently a boom in ads for drigs to treat fibromyalgia. This condition is yet another one of mysterious origins, at least according to mainstream medicine. The treatment consists mainly of GABA agonists like Lyrica but the official version is (of course) that there is no … Read more Fibromyalgia may be simply a sign of insulin resistance