A very interesting study, which suggests niacinamide may be a treatment for depression. Strikingly, the almost 50% reduction in depressive symptoms occurred after just 4 weeks of consuming vinegar – a feat that almost no pharma antidepressant drug can currently match. I just hope the takeway from the blog post -is to use niacinamide for depression, instead of vinegar, since high levels of acetic acid promote fat synthesis and tumor growth and as such chronically elevated vinegar intake is probably not safe. The mechanism of action is mostly likely linked to the role of niacinamide as an NAD+ precursor, resulting in improved metabolism/OXPHOS. Of course, that strongly suggests (yet again) that depression is a metabolic disease:-)
https://www.mdpi.com/2072-6643/16/14/2305
https://www.phillyvoice.com/vinegar-depression-mood-mental-health/
“…A few tablespoons of vinegar a day may help keep depression away, research shows. Consuming two tablespoons of red wine vinegar twice a day for four weeks significantly improved self-reported depression scores in a group of 28 overweight adults who were otherwise healthy, a new study found. Enhancements in niacin metabolism may contribute to the improvement in mood, the researchers concluded.”
“…Vinegar, a combination of acetic acid and water made through fermentation, previously has been linked to positive outcomes for heart disease and weight loss. For the latest study, published in the journal Nutrients, researchers from the University of Arizona looked at how daily vinegar consumption affected mood and metabolism. They compared one group of people who took diluted vinegar daily to a second group that ingested a pill containing very little vinegar. By the fourth week, the group taking the diluted vinegar showed a 42% reduction in depression scores compared to an 18% reduction in the group taking pills. The group that drank the vinegar daily also experienced an 86% increase in levels of nicotinamide, a form of vitamin B that has been linked to anti-inflammatory effects.”
