Niacinamide as effective as minoxidil at treating “androgenic” hair loss

The actual molecule used was nicotinamide mononucleotide (NMN). However, not only is NMN very expensive, but the FDA recently classified it as a drug so it can no longer be obtained freely by people interested in experimenting. The good news is that plain niacinamide (NAM) has almost identical physiological effects compared to NMN and prior studies have also shown hair-growth promoting effects of NAM, though mostly in auto-immune conditions such as alopecia areata. Anyways, the study below used a simple solution with 1% concentration of NMN in saline water and applied that solution topically on the hairless skin once daily for 2 weeks. The results were accelerated hair growth comparable to minoxidil in magnitude and speed of regrowth, and there was no toxicity or side effects related to the NMN treatment (both in-vitro and in-vivo). The findings of the study match the reports we get from clients in regards to our product SolBan (contains niacinamide), which they say strongly stimulated regrowth of hair in even advanced cases of androgenic alopecia (hair loss).

“…The double-blind experiment revealed that mice exposed to hair removal exhibited a cessation in hair growth. However, the administration of NMN at a specific concentration in the NMN groups stimulated hair growth during the growth phase, similar to the effects observed in the control and blank groups. The effects of NMN were comparable to those of minoxidil. In the in vitro HDPCs experiment, a concentration of 2.5 mg/mL of NMN significantly increased VEGF secretion from HDPCs by 65.19% in comparison to the control groups. Additionally, the IL-6 content notably decreased with an inhibition rate of 13.60%. NMN was observed to downregulate the expression of DKK-1 and AR genes by 75.16% and 41.78%, respectively. Furthermore, there was a significant upregulation of β-catenin expression at a rate of 125.71%. These findings demonstrate that at this concentration, NMN inhibits IL-6 secretion while promoting the upregulation of VEGF and β-catenin gene expression, and simultaneously downregulating the expression of DKK-1 and AR genes. This mechanism contributes to the anti-hair loss effect of NMN, thereby achieving the desired preventative effect. Moreover, the cytotoxicity MTT test revealed that the administered experimental concentration of NMN did not induce any cellular toxicity.”

Author: haidut