Endotoxin (LPS) as a cause of systemic inflammation seen in obesity

Yet another study implicating the great villain of systemic health – endotoxin / LPS. It is well-known that most people with obesity have high levels of inflammatory biomarkers both in their tissues and bloodstream. The study below demonstrates that the inflammation seen in adipose tissue of obese organisms is likely due to endotoxin / LPS. … Read more Endotoxin (LPS) as a cause of systemic inflammation seen in obesity

Endotoxin behind the mortality of Black Death and 1918 Flu pandemics

As many of my readers know, many/most people dying from COVID-19 develop either sepsis and/or respiratory failure. Endotoxin (LPS) is now a known cause behind both of these conditions, as a virus by itself has no known mechanism of causing a cytokine storm. As much as I revile the term “scientific consensus”, in this case … Read more Endotoxin behind the mortality of Black Death and 1918 Flu pandemics

Sugar (sucrose) lowers stress-induced cortisol

Just a quick post to give some props to the much-vilified sucrose. The study below demonstrates that sucrose consumption for just 3 days prior, blunted most of the negative effects of stress, and especially the rise in plasma cortisol. The HED of sucrose was about 4g/kg, which matches closely Peat’s recommendations that consumption of 350g-400g … Read more Sugar (sucrose) lowers stress-induced cortisol

Some aromatase inhibitors (AI) are estrogenic

I have long suspected this considering the peculiar side effects of some AI drugs, but was not able to find concrete evidence…until now. The study below demonstrates that one of the most widely used AI – anastrozole – is a potent estrogen receptor activator/agonist, and at low concentrations too. At higher concentrations, the estrogenic effects … Read more Some aromatase inhibitors (AI) are estrogenic

Even “non-carcinogenic” estrogens can cause cancer

I know, the title is a “paradox”, but this is truly what the article discusses. By now, we already know that the word “paradox” in science is just a euphemism for idotism and/or fraud. Apparently, mainstream medicine has managed to convinced the public somehow that there are carcinogenic and non-carcinogenic estrogens. An example of the … Read more Even “non-carcinogenic” estrogens can cause cancer

Reduced pyruvate and/or increased lactate drive heart failure

I just did a post on the role of reduced glucose metabolism, lower pyruvate/NAM/NAD and elevated lactate in the pathogenesis of glaucoma. Just minutes later, another study popped up in my newsfeed. Namely, a study that demonstrates the exact same metabolic disturbances as the main drivers of heart failure. The study below demonstrates that heart … Read more Reduced pyruvate and/or increased lactate drive heart failure

Glaucoma likely a metabolic disease, treatable by pyruvate and/or niacinamide

About a year ago, a publication came out that demonstrated therapeutic effects of raising the (mitochondrial) NAD/NADH ratio in glaucoma patients. That study used niacinamide (NAM) and suggested that the “irreversible” changes in eye structure seen in glaucoma patients are in fact nothing more than a downstream effect of metabolic (OXPHOS) disturbances. Now, a new … Read more Glaucoma likely a metabolic disease, treatable by pyruvate and/or niacinamide

Heart attack survivors have high stress (cortisol/adrenaline) hypersensitivity, low androgens

A very interesting study that highlights yet again the connection between chronic stress and ill systemic health, especially cardiovascular disease (CVD). The study demonstrates that people who had experienced a heart attack have dramatically higher higher cortisol and adrenaline/noradrenaline levels, combined with low levels of androgens such as testosterone and DHEA a full 6 months … Read more Heart attack survivors have high stress (cortisol/adrenaline) hypersensitivity, low androgens

Stress-driven lipid peroxidation, inflammation re-awakens dormant cancer cells

Yet another study demonstrating that stress is anything but benign or irrelevant for chronic diseases, especially for cancer. The study below demonstrates that stress-induced increases of epinephrine and norepinephrine results in increased lipolysis and a cascade of pro-carcinogenic downstream effects. Now, if the fat released as a result of the increased lipolysis was fully saturated … Read more Stress-driven lipid peroxidation, inflammation re-awakens dormant cancer cells

Niacinamide may treat ALS by improving energetic state

Another study sent to me by the Austrian collaborator. Once again, the energetic origin of “incurable” diseases like amyotrophic lateral sclerosis (ALS) is on full display. The study elucidates that ALL types of ALS are characterized by metabolic/energetic abnormalities and the metabolic phenotype of that disease is indistinguishable from cancer. In other words, little to … Read more Niacinamide may treat ALS by improving energetic state