SHBG may be a good test for liver (metabolic) health

A very good study, which probably runs counter to the “mantra” most bodybuilders adhere to – i.e. they would say one must keep their SHBG low in order to increase levels of “free” steroids since, the claim goes, only free steroids are active and capable of influencing cells. If SHBG is high, the claim is … Read more

DHT blocks, androgen antagonists promote breast cancer

The first claim of the title is already well-known to my readers and to clinical practice. DHT was clinically used back in the middle of the 20th century as a treatment for breast cancer, and the synthetic androgen Drostanolone (Masteron), which still retains its approval by FDA for breast cancer treatment, is a simple DHT … Read more

Niacin / niacinamide ratio may be a very good test for bacterial infection

A very interesting study, which may provide a cheap, fast and easy method for testing whether a person has a bacterial or not. This is very useful in cases of respiratory diseases where a clinician has to determine if the respiratory infection is of bacterial or viral origin, in order to decide if prescribing antibiotics … Read more

Milk or water are optimal drinks for (oral) vitamin D bioavailability

Just a quick post about something I thought many people will probably find interesting, considering the widespread use of oral vitamin D supplements. The findings of the study are a bit surprising, considering that vitamin D is one of the “fat-soluble” vitamins and as such is expected to be poorly absorbed from the GI tract … Read more

The “burning mouth” syndrome may be due to vitamin deficiencies, hypothyroidism

Just a quick post since I get a lot of emails about this issue, and apparently the rates have increased a lot since the pandemic began. According to the study below, this symptoms can be caused by insulin resistance, vitamin D/B6/B1 or zinc deficiencies, or hypothyroidism (high TSH). Looking at those issues, one immediately sees … Read more

PUFA is part of spike protein, PUFA restriction may treat COVID-19

A pair of studies forwarded by one of my readers. The first one discovered that a PUFA – linoleic acid – is part of the structure of the spike protein. The latter is perhaps the most pathogenic portion of the SARS-CoV-2 virus and likely responsible for causing most of the symptoms now known as COVID-19. … Read more

Just a week-long break from social media alleviates anxiety and depression

I don’t think this study will come as a surprise to my readers, but it still helps to have some peer-reviewed evidence confirming what many people intuitively sense, yet are afraid to verbalize due to FOMO or being ostracized – i.e. social media, and digitization in general, is a bane on human consciousness and its … Read more

Hypogonadism in older males due to low OXPHOS

I suspect many readers will simply say “duh!”, but believe or not the origin of age-related hypogonadism in males is still considered unknown. Most endocrinologists have discovered experimentally that treating their patients with SERM or AI drugs restores androgens to youthful levels, but the actual cause of this decline in androgens in the first place … Read more

Lipolysis preferentially releases PUFA from adipose tissue

…compared to SFA and/or MUFA. This topic is considered highly controversial in Peat-land, mostly because of the dearth of studies dealing with it. I must have received hundreds of emails at this point criticizing Peat’s stance on this issue and claiming that there is no evidence for preferential PUFA release from adipose tissue compared to … Read more

Stearic acid (SA) is an estrogen receptor antagonist

Over the last year or so I stumbled upon a few studies claiming both SA (C18:0) and its methyl ester are capable of binding the estrogen receptors (ER) and modulate their transcription effects. However, those studies did not evaluate if SA acted as an agonist or antagonist on those receptors. So, I did a little … Read more