Inflammation (from PUFA), not telomeres, determines lifespan / healthspan

The idea of lifespan being entirely determined by limits on cellular division has ruled biology for more than a century and is perhaps best exemplified by the (in)famous (and false) Hayflick limit. Reaching the said limit is postulated to be controlled by telomere length, and as such the simplistic hypothesis materialized that could extend/control lifespan … Read more

DHT, not T, likely the “active” androgen in heart and brain

Interesting study, done on baboons (so should have good relevance for humans), demonstrating that the cardiovascular system (CVS) exclusively accumulates and recognizes (at the receptor level) DHT, instead of testosterone (T). In fact, the androgen receptor in CVS is so structurally different it apparently cannot even bind T. Recent studies with ALS patients suggest the … Read more

Estrogens cause obesity / PCOS in women, DHT is protective

Female obesity and the closely related condition PCOS are perhaps the female equivalent of the so-called “androgen hypothesis” for balding and prostate cancer in men, as the female version of this hypothesis not only blames androgens for these conditions but specifically singles out DHT as the main “villain”. The mainstream medical dogma is that a … Read more

Stress causes/exacerbates allergies, pregnenolone/progesterone therapeutic

Yet another studies demonstrating the “controversial” link between stress and a condition doctors insist has nothing to do with stress or hormones in general. This time the culprit is CRF/CRH, which is the initial step in the “stress” cascade and is now known to be implicated in conditions such as multiple sclerosis (MS), Alzheimer, depression … Read more

Low DHT can cause hypogonadism symptoms even in eugonadal men

Seemingly contradictory title, but the study findings are pretty clear. Namely, even in males with normal testosterone levels there is a direct inverse relationship between DHT levels and symptoms of hypogonadism such as sexual dysfunction and “aging male” syndrome. For every 10% increase in DHT levels there was a 4.67% decrease in hypogonadism symptoms of … Read more

Stress (cortisol) causes hair loss

Amazing study, which perfectly corroborates the findings of a previous study showing that estrogen (a cortisol promoter) also causes hair loss, while administering an estrogen-blocker reversed the hair loss. Administration of androgens (known cortisol and estrogen blockers) such as testosterone had similar effects, and even the “hair villain” DHT robustly promoted hair growth. Cortisol is … Read more

Endocrine disruptors in cosmetics may cause postpartum depression, premature births

Hardly a surprising finding, but it will probably come as a shock to most modern women who are the biggest consumers of such products (e.g. nail polish, perfumes, shampoo, etc). One of the reasons for this “controversy” is that doctors continue to insist that using such products during pregnancy is perfectly safe, for both mom-to-be … Read more

Vitamin D (topical) safe and effective for removing scars

A neat human study, which demonstrates that topical treatment with vitamin D may treat even large scars that have been present on the skin for years. Many people have such scars as a result of surgery, trauma, chemical/heat burns, radiation, etc. As the study says, the typical treatment is with cortisol injections, however the effectiveness … Read more

Serotonin and oxytocin promote gullibility, trainability, and servility

A great study, which while done with horses, will probably raise questions (unfortunately only in people with already-low serotonin) of whether the relentless promotion of serotonin (5-HT) as the “happiness hormone” and oxytocin as the “love and connection hormone” has any evidence in support. According to the study, the horses with the lowest serotonin levels … Read more

Vitamin D deficiency impairs muscles by lowering energy production

Perhaps this study below will put some of the arguments against vitamin D supplementation to rest. It demonstrated up to 40% reduction of energy production in the muscles of animals deficient in vitamin D, in spite of unchanged number/size/density of mitochondria inside the cells. In addition, it demonstrated decrease in lean mass in the deficient … Read more