Estrogen excess during pregnancy may cause autism

Finally! Some common sense is emerging from the medical profession. For one, it points the finger straight at estrogen as a possible cause of autism. And not just estradiol, which the medical profession considers the only estrogen of note, but all 3 of them (estrone, estradiol, estriol). So, all the talk about estrone/estriol being weak … Read more

Progesterone may bind and deactivate endotoxin (LPS) directly

I made a few posts recently discussing the blocking effects of pregnenolone on TLR4 and TLR family receptors in general, and the reduction of systemic inflammation stemming from this blockade/regulation. It is well-known that glucocorticoids and mineralocorticoids are protective against endotoxemic shock, possibly due to blocking the hypotensive and inflammatory effects of endotoxin. However, … Read more

(Sometimes) to do nothing as cancer treatment is also good medicine

Just a week ago I made post about a book calling for all but the abolition of the medical system. The evidence for any systemic benefit are just not there, while the evidence for iatrogenic harm and death, as well as astounding financial costs, is abundant. A call for medical nihilism – to do nothing … Read more

Avoiding sunlight may be as bad for health as smoking a pack a day

As most readers of this blog know, the current recommendations of the American Dermatology Association (ADA) call for pretty much no sun exposure of any skin areas unless those areas have been “protected” by sunscreen. The same recommendation applies to tanning beds and makes not distinction of a person’s place of living. In other words, … Read more

The stereotypes about testosterone (T) are likely wrong

A really great study for a number of reasons. Not only does it show that the commonly cited stereotypes about T’s effects on human behavior are likely all wrong, but it also demonstrates the powerful effects the process of “pre-registering” has on study outcomes. The process of pre-registering involves the scientists submitting a priori their … Read more

Parents’ emotional trauma may change their children’s biology

Not a new idea, but the study is a nice summary of recent work in the area and demonstrates that the old gene-centric idea of inheritance is slowly being replaced by a much richer theory of how organisms interact with their environment and how they pass this information down to generations. It is a very … Read more

Gorillas have developed human-like “societies” that are not based on kin

One of the central dogmas in biology is that any large number of animals behaving as a group in deliberate manner, spanning multiple generations, is invariably based on kin. The dogma argues that this is the only way individual survival and procreation can take a back stage to the interests of the group as a … Read more

Niacinamide may improve symptoms of ALS

Just over a week ago I posted a thread on ALS being linked to increased fatty acid oxidation (FAO) and as such a decreased glucose availability/oxidation. Now, the study below further corroborates this FAO-disease association by demonstrating a causative link between a change in the microbiome and the development/progression of ALS. The change in … Read more

Imagination is crucial for altruism

A great study that once again links altruistic behavior with metabolism and energetics. I posted in the past about the studies on egalitarian beliefs / attitudes being more energetically expensive than selfish ones, and as such implying that people with the former beliefs are in better metabolic health. Egalitarian Values Require Mental Effort: Research suggests … Read more

A call for medical nihilism – to do nothing is also good medicine

To my greatest surprise, I stumbled upon yet another article in the Scientific American (SCIAM) that looked completely out of place in that publication. After all, SCIAM was (and continues to be) a bastion of official medicine and its articles often read more like drug company brochures than discussions on serious scientific matters. Yet, here … Read more