Fasting causes aging by energy depletion, vitamin B2 can stop it

Well, if this title does not rile up the fasting crowd, I don’t know what will:-) Aside from that controversy, it is actually a great study that not only suggests a dirt cheap and widely available option for retarding aging, but once again demonstrates that stress (e.g. fasting) directly causes aging by depleting/blocking OXPHOS, and … Read more

Fasting / stress decimate gonadal steroidogenesis, with no effect on blood cortisol

A very interesting and very “controversial” (read: inconvenient truth) study, since it shows beyond reasonable doubt that even brief (4 days) fasting is a form of severe stress, at least when it comes to endocrine health. The study may also provide answers to various endocrine “mysteries” becoming more common among the male population of “developed” … Read more

DHT may treat thyroid cancer

Yet another “non-endocrine” tumor turns out to be anything but. Thyroid cancer rates have been rising for the last 30 years and parallel the increase in diagnoses of its likely precursor – i.e.  the “autoimmune” disorder Hashimoto Disease. While there is solid evidence implicating endocrine disruptors, especially from plastics (proven to have estrogenic, anti-androgenic, and … Read more

DHT as anti-inflammatory as cortisol, but without the side effects

As most of my readers know, glucocorticoids (synthetic or bioidentical) are widely used clinically and there is hardly a chronic conditions for which they are not prescribed even if only for managing brief “acute exacerbations”. Despite mainstream medicine doing everything it can to conceal the massively pathogenic effects of those steroids, even seasoned doctors would … Read more

DHT can stop aging of the pancreatic beta-cells (insulin-producing)

Another great study, which demonstrates that far from being a “villain” (in both males and females) DHT is in fact a crucial and positive factor in health. In this specific study below, it was demonstrated that DHT dose-dependently inhibited the aging/dysfunction of the pancreatic beta-cells, and the highest dose of DHT tested completely stopped that … Read more

Scoliosis (even in females) may be driven by low androgen levels, DHT may treat it

I am posting about this condition as it seems recently its numbers have absolutely exploded in the general population. Scoliosis used to be a relatively uncommon condition, usually present in adults over the age of 50. Mainstream medicine has no explanation for its possible causes, but suspects inflammation is involved. The study below suggests that … Read more

Cancer cells deprive immune cells of energy by devouring their mitochondria

In a description that could be a good plot for a horror-movie, the study below demonstrates that the immune failure often seen in cancer is, again, bioenergetic in origin. More specifically, the immune system cells are getting literally the energy (i.e. mitochondria) sucked out of them by cancer cells using tiny, nano-sized tentacles (a trunk … Read more

Oral allopregnanolone coming soon to a pharmacy near you

Kidding aside, it looks like pharma companies are starting to develop a very strong interest in oral delivery of steroids, using the technique described by Peat decades ago to bypass the first-pass metabolism in the liver. Namely, as Peat described, mixing a steroid (or another molecule) with long(er) chain fats (chain length 12 or more) … Read more

Niacinamide + pyruvate may treat glaucoma (human study)

Some excellent results from a human clinical trial. Namely, a combination of 3g niacinamide and 3g (calcium) pyruvate daily demonstrated significant therapeutic effect in patients with already established glaucoma. I can’t access to actual study link on JAMA, but I suspect the mechanism of action is, again, improved bioenergetic state with niacinamide raising the NAD/NADH … Read more