Vitamin B3 remarkably therapeutic for brain cancer (glioblastoma)

As many of my readers know, brain cancer rates have been steadily rising over the last 3 decades and are now a leading cause of death in both elderly and also very young people. The most common (and deadly) form of brain cancer is glioblastoma multiforme and the average life expectancy after diagnosis is just … Read more Vitamin B3 remarkably therapeutic for brain cancer (glioblastoma)

Niacinamide may treat fibrotic eye disease and prevent vision loss

A great new study that demonstrated nicotinamide (NAM) may also have anti-fibrotic effects in addition to its positive effects on maintaining favorable NAD/NADH ratio and redox balance. The mechanism of action of NAM was inhibition of the TGF-β pathway and overall reduction of inflammation. This anti-fibrotic effect of NAM may explain its well-known protective effects … Read more Niacinamide may treat fibrotic eye disease and prevent vision loss

Low-dose (but not high) niacinamide reverses reproductive decline in old females

A great new study, which once again confirms the importance of metabolism in “aging” disorders such as infertility (both female and male) and menopause. More specifically, it was the increase in NAD/NADH ratio that was the main mechanism of action behind the beneficial effects of nicotinamide mononucleotide (NMN) the study below discovered. Now, the study … Read more Low-dose (but not high) niacinamide reverses reproductive decline in old females

Dietary niacinamide (B3) deficiency may be a cause of schizophrenia

As many of my readers know, the link between niacinamide and schizophrenia dates back at least the 1950s and possibly much earlier. The late Abram Hoffer, one of the founders of the orthomolecular approach, was convinced that stress was a huge factor in mental illness and ran several successful trials with high dose niacin/niacinamide as … Read more Dietary niacinamide (B3) deficiency may be a cause of schizophrenia

Niacinamide may improve symptoms of ALS

Just over a week ago I posted a thread on ALS being linked to increased fatty acid oxidation (FAO) and as such a decreased glucose availability/oxidation. http://haidut.me/?p=239 Now, the study below further corroborates this FAO-disease association by demonstrating a causative link between a change in the microbiome and the development/progression of ALS. The change in … Read more Niacinamide may improve symptoms of ALS