Reduced pyruvate and/or increased lactate drive heart failure

I just did a post on the role of reduced glucose metabolism, lower pyruvate/NAM/NAD and elevated lactate in the pathogenesis of glaucoma. Just minutes later, another study popped up in my newsfeed. Namely, a study that demonstrates the exact same metabolic disturbances as the main drivers of heart failure. The study below demonstrates that heart … Read more Reduced pyruvate and/or increased lactate drive heart failure

Glaucoma likely a metabolic disease, treatable by pyruvate and/or niacinamide

About a year ago, a publication came out that demonstrated therapeutic effects of raising the (mitochondrial) NAD/NADH ratio in glaucoma patients. That study used niacinamide (NAM) and suggested that the “irreversible” changes in eye structure seen in glaucoma patients are in fact nothing more than a downstream effect of metabolic (OXPHOS) disturbances. Now, a new … Read more Glaucoma likely a metabolic disease, treatable by pyruvate and/or niacinamide

Low energy production (glucose metabolism) may cause andropause

As many of my readers know, aging men can also experience the equivalent of menopause and doctors informally call that state “andropause”. Its official name is age-related hypogonadism and most of that hypogonadism is of the “secondary” type – i.e. the gonads appears to be in fine shape but for some “unknown” reason they do … Read more Low energy production (glucose metabolism) may cause andropause

The Cure for Aging Might be the Cure for Alzheimer’s

Almost 25 years ago, Dr. Peat himself wrote a 2-article series in which he outlined arguments in favor of the hypothesis that aging and Alzheimer Disease (AD) are just examples of a more and less systemic sign respectively of declining energy production, and that curing one would lead to a cure of the other. http://raypeat.com/articles/articles/alzheimers.shtml … Read more The Cure for Aging Might be the Cure for Alzheimer’s

Red light therapy for Parkinson Disease (PD) begins human trials

A few weeks ago, I posted about a human study demonstrating reversal of age-related vision decline by staring at a red light for just a few minutes a day. The mechanism of action proposed in that study had to do with improved mitochondrial function and energy production. Now, it seems another branch of medicine – … Read more Red light therapy for Parkinson Disease (PD) begins human trials

Declining vision from aging can be restored by staring at red light

The rates of cataracts, glaucoma, and other vision problems continue to rise and the increasingly aging world population will likely see this problem worsen in the coming years/decades. As such, therapeutic interventions that improve vision are desperately needed. The study below now adds declining vision to the list of problems now known to be caused … Read more Declining vision from aging can be restored by staring at red light

Mad cow disease may be a mitochondrial/metabolic issue

Peat has mentioned the Creutzfeldt-Jacob disease (CJD) / BSE in several of his articles and interviews and has explained how environmental stress, estrogen, PUFA, ionizing radiation, etc can cause metabolic derangements resulting in the same brain damage so characteristic of this pathology. The public is more familiar with that pathology under the name of mad … Read more Mad cow disease may be a mitochondrial/metabolic issue

Raising NAD levels may be therapeutic for COVID-19

A rather timely study, which demonstrates once again the crucial role energy plays even in “non-metabolic” diseases such as viral infections. At this point, even mainstream medicine admits that every function of the organism requires energy, so it would be plausible to expect an organism with higher energy reserves to be better able to defend … Read more Raising NAD levels may be therapeutic for COVID-19

Restoring metabolism prevents / reverses “permanent” nerve damage

Yet another study demonstrating the crucial role cellular metabolism plays in pathological processes. While most of the posts on this blog deal with beneficial effects of improving OXPHOS on various chronic diseases, the study below demonstrates that the same may be true in acute pathologies such as traumatic injury, especially in tissues with high energy … Read more Restoring metabolism prevents / reverses “permanent” nerve damage

Increasing metabolism may reverse Alzheimer Disease (AD) and general aging

Yet another study demonstrating the remarkable parallels between the decline in function (metabolism) and the structural abnormalities that occur not only in specific pathologies such as AD but also in the generalized degradation known as “aging”. FDA currently does not recognize aging as a disease, but the evidence for it is rapidly accumulating. Just a … Read more Increasing metabolism may reverse Alzheimer Disease (AD) and general aging