Restoring metabolism prevents / reverses “permanent” nerve damage

Yet another study demonstrating the crucial role cellular metabolism plays in pathological processes. While most of the posts on this blog deal with beneficial effects of improving OXPHOS on various chronic diseases, the study below demonstrates that the same may be true in acute pathologies such as traumatic injury, especially in tissues with high energy … Read more Restoring metabolism prevents / reverses “permanent” nerve damage

Increasing metabolism may reverse Alzheimer Disease (AD) and general aging

Yet another study demonstrating the remarkable parallels between the decline in function (metabolism) and the structural abnormalities that occur not only in specific pathologies such as AD but also in the generalized degradation known as “aging”. FDA currently does not recognize aging as a disease, but the evidence for it is rapidly accumulating. Just a … Read more Increasing metabolism may reverse Alzheimer Disease (AD) and general aging

Male fertility depends on intensity of (sperm) metabolism

Yet another aspect of health that turns out to be directly controlled by quality/speed of metabolism. I made a few posts in the past demonstrating that progesterone and pregnenolone activate a calcium channel (CatSper) specific to progesterone, which greatly increases sperm motility. https://www.nature.com/articles/nature09767 https://www.sciencedaily.com/releases/2016/03/160317150803.htmhttps://www.sciencedaily.com/releases/2016/03/160317150803.htm However, I suspected that this is not the whole story behind … Read more Male fertility depends on intensity of (sperm) metabolism

Dietary niacinamide (B3) deficiency may be a cause of schizophrenia

As many of my readers know, the link between niacinamide and schizophrenia dates back at least the 1950s and possibly much earlier. The late Abram Hoffer, one of the founders of the orthomolecular approach, was convinced that stress was a huge factor in mental illness and ran several successful trials with high dose niacin/niacinamide as … Read more Dietary niacinamide (B3) deficiency may be a cause of schizophrenia

Energy deficiency due to stress causes anxiety, panic disorders, and subbordination

This is a great study on so many levels. First, it directly demonstrates that chronic stress leads to mitochondrial dysfunction and reduced oxidative phosphorylation. Second, it demonstrates that glucocorticoids (cortisol) are a direct cause of this energy production downregulation. Third, it demonstrates a direct parallel between animal models and human mood/mental disorders by comparing the … Read more Energy deficiency due to stress causes anxiety, panic disorders, and subbordination

Allopregnanolone as a treatment of Alzheimer Disease (AD)

It looks like the recent FDA approval of allopregnanolone (ALLO) for postpartum depression may open the floodgates to ton of new research with this steroid, as well as with its reliable precursors such as pregnenolone and progesterone. I posted several studies in the past demonstrating that pregnenolone, progesterone and ALLO are all endotoxin antagonists and … Read more Allopregnanolone as a treatment of Alzheimer Disease (AD)

Niacinamide may restore female fertility in old age

The mainstream medical dogma is that after the onset of menopause, female reproductive potential is essentially zero. I posted a thread recently that challenged that dogma and demonstrated that infertility is essentially an energetic dysfunction process and can be reversed with exposure to red light. Fertility depends on metabollism (ATP), not age Now, the study … Read more Niacinamide may restore female fertility in old age

Inhibiting fatty acid synthesis (FAS) dramatically improves sepsis survival rate

Yet another study that points the finger straight at fat as a key factor in one of the most common causes of inpatient hospital mortality – sepsis. Sepsis is currently considered to be a condition of infectious (bacterial) etiology, driven by endotoxin. However, in light of the new findings it may be more appropriate to … Read more Inhibiting fatty acid synthesis (FAS) dramatically improves sepsis survival rate

Imagination is crucial for altruism

A great study that once again links altruistic behavior with metabolism and energetics. I posted in the past about the studies on egalitarian beliefs / attitudes being more energetically expensive than selfish ones, and as such implying that people with the former beliefs are in better metabolic health. Egalitarian Values Require Mental Effort: Research suggests … Read more Imagination is crucial for altruism

Increased fat oxidation (FAO) does not lead to weight/fat loss

The study below directly contradicts a mantra commonly repeated in nutrition circles – restrict glucose and increase fat oxidation in order to lose weight, and more specifically body fat. In fact, this idea is so ingrained into the minds of most people that I often get hate mail from people all over the world angrily … Read more Increased fat oxidation (FAO) does not lead to weight/fat loss