To Extract Knowledge from Matter
Perceive, Think, Act
I just did a post on the role of reduced glucose metabolism, lower pyruvate/NAM/NAD and elevated lactate in the pathogenesis of glaucoma. Just minutes later, another study popped up in my newsfeed. Namely, a study that demonstrates the exact same metabolic disturbances as the main drivers of heart failure. The study below demonstrates that heart … Read more Reduced pyruvate and/or increased lactate drive heart failure
About a year ago, a publication came out that demonstrated therapeutic effects of raising the (mitochondrial) NAD/NADH ratio in glaucoma patients. That study used niacinamide (NAM) and suggested that the “irreversible” changes in eye structure seen in glaucoma patients are in fact nothing more than a downstream effect of metabolic (OXPHOS) disturbances. Now, a new … Read more Glaucoma likely a metabolic disease, treatable by pyruvate and/or niacinamide
A very interesting study that highlights yet again the connection between chronic stress and ill systemic health, especially cardiovascular disease (CVD). The study demonstrates that people who had experienced a heart attack have dramatically higher higher cortisol and adrenaline/noradrenaline levels, combined with low levels of androgens such as testosterone and DHEA a full 6 months … Read more Heart attack survivors have high stress (cortisol/adrenaline) hypersensitivity, low androgens
Yet another study demonstrating that stress is anything but benign or irrelevant for chronic diseases, especially for cancer. The study below demonstrates that stress-induced increases of epinephrine and norepinephrine results in increased lipolysis and a cascade of pro-carcinogenic downstream effects. Now, if the fat released as a result of the increased lipolysis was fully saturated … Read more Stress-driven lipid peroxidation, inflammation re-awakens dormant cancer cells
Another study sent to me by the Austrian collaborator. Once again, the energetic origin of “incurable” diseases like amyotrophic lateral sclerosis (ALS) is on full display. The study elucidates that ALL types of ALS are characterized by metabolic/energetic abnormalities and the metabolic phenotype of that disease is indistinguishable from cancer. In other words, little to … Read more Niacinamide may treat ALS by improving energetic state
A very interesting study, sent to me by a collaborator who lives in Austria. It demonstrated that depression is accompanied by increased SIRT1 activity (i.e. increased fatty acid oxidation), lower ATP levels and redox balance shifted towards reduction. The study demonstrated that animals without the SIRT1 gene were highly resistant to depression and had high … Read more Niacinamide may treat depression by improving energetic state
The study below tried to tease out the main factors affecting the longevity of the legendary naked mole rat – the animal with longest lifespan in its genus, and the sole mammal known to be virtually immune to developing cancer. Most of the biological/biochemical findings in regards to naked mole rats have already been found … Read more Sexual activity and stress levels (HPA activity) may determine longevity
A pair of studies by a group of scientists in Brazil. They used intratumoral injections of a 5% aspirin or 5% acetic acid (vinegar) solution in the first study, and 10% solutions of each in the second study. EITHER treatment not only destroyed the tumor within 24 hours but after 7 days all the biochemical … Read more Aspirin can cure liver cancer in just 24 hours (in rabbits)
A great new study that demonstrates the strong protective effects of glycine, alone or in combination with leucine, on preventing/treating various forms of fatty liver disease, as well as the obesity that often accompanies these conditions. One of the strong points of the study is that it also established a minimum daily dosage needed to … Read more Glycine (and leucine) can treat fatty liver (NAFLD and NASH)
This study alone explains so much of the pathological behavior seen in humans living in developed countries. Namely, the vast majority of them are willing to break their backs working and “delaying gratification” in the hopes that one day they will “make it” and all of their efforts will be generously rewarded. Of course, this … Read more Serotonin promotes (futile) patience and (false) faith in future rewards