Cancer cells deprive immune cells of energy by devouring their mitochondria

In a description that could be a good plot for a horror-movie, the study below demonstrates that the immune failure often seen in cancer is, again, bioenergetic in origin. More specifically, the immune system cells are getting literally the energy (i.e. mitochondria) sucked out of them by cancer cells using tiny, nano-sized tentacles (a trunk … Read more

Uncoupling metabolism/OXPHOS may treat inflammatory conditions

In several of his articles and interviews, Peat mentioned that one of the reliable signs/symptoms of low metabolism is the presence of low-grade chronic inflammation. Basically, the cell is stuck into a constant (and futile) repair process as it cannot complete it properly after discovering the injury/infection due to lack of sufficient energy reserves. The … Read more

Restoring oxidative metabolism has curative effects on cancer (leukemia)

A great study, which directly demonstrates not only the OXPHOS deficiency characteristic of all “cancer” cells, but also proving that restoration of OXPHOS is highly therapeutic (and likely curative) for leukemia. Just as importantly, the study demonstrates that cancer cells have, in fact, higher respiration rates than normal cells, however the mitochondria of cancer cells … Read more

Cartilage/bone health depends on oxidative metabolism

A good study that demonstrates yet another “structural” aspect of health – the strength and growth or our cartilage/bones – is heavily dependent on proper mitochondrial function. As such, even minor disruptions of oxidative metabolism can lead to long-term deformations in bone/cartilage, which is often corroborated by the facial deformities and other bone pathologies in … Read more

Infrared/red light applied to the skull can treat Alzheimer’s/dementia…

…and improve cognition even in healthy people! The mechanism of action is the familiar effects of red/infrared light on stimulating mitochondrial function, and especially complex IV, while also decreasing chronic inflammation. The regimen was light exposure for 6min, twice a day, for 4 weeks. Even a single 100W red bulb should be enough to replicate … Read more

How lipolysis may damage organs such as the heart

It is well-known in endocrinology, and especially among doctors specializing in diabetes, that excessive lipolysis is highly detrimental not only for the overall progression of metabolic diseases like diabetes, but also for most of the organs of the patient. Lipolysis is known to be elevated in most obese people, and especially in people with diabetes. … Read more

Cellular “memory” of stress can be passed on for 50+ generations

There was a study that came out 2-3 years ago showing that when animals were exposed to a toxin, often the negative effects did not even manifest in the directly exposed organism but manifested in their offspring and were passed on for more than 14 generations. The study below now demonstrates that the effects of … Read more

Intense exercise causes mitochondrial damage even in elite athletes

Hopefully, this post won’t be interpreted as trying to bash exercise. Its goal is to simply draw attention to the fact that intense exercise can be detrimental even for elite athletes. While the damage the study observed was temporary, it is now known that (just like ionizing radiation) the damage of chronic stress / overtraining … Read more

Damaged mitochondria may cause 90%+ of Parkinson Disease (PD) cases

More evidence that yet another “incurable” condition is little more than energy deficit (due to mitochondrial dysfunction) in disguise. In this case the mitochondrial dysfunction was caused by accumulation of mitochondrial debris inside the cell, which has been repeatedly shown by other studies (and discussed on this blog) to be due primarily to chronic stress. … Read more

Aging is an energy deficiency problem, taking cardiolipin may reverse it

Yet another study demonstrating that “aging” is nothing but a phenotype characterizing an organism with declining energy production. Since most of the cellular energy is produced in the mitochondria, another way of stating the same is that aging (and any specific disease for that matter) is a mitochondrial dysfunction problem. Conversely, reversing that energy/mitochondrial deficiency … Read more