Serotonin antagonists as treatment for COVID-19 / SARS

A quick post to let my Twitter followers know that serotonin is implicated in viral diseases as well. I have posted in the past about the therapeutic effects of cyproheptadine and Benadryl on severe viral infections such as Ebola, HIV or even rabies. The serotonin antagonist below has already been observed to treat SARS caused by viruses such as the coronavirus. Dr. Peat mentioned it in several of his recent interviews as potential treatment of COVID-19. While cinanserin is not available commercially, the benefits of this chemical seem to stem from its 5-HT2 antagonism so any other chemical with similar pharmacological profile should have similar effects.

“…Cinanserin (INN) is a 5-HT2A and 5-HT2C receptor antagonist which was discovered in the 1960s.[1] The molecule is an inhibitor of the 3C-like protease of SARS-coronavirus (SARS).[2]

Author: haidut