Blocking serotonin, adrenaline treats anxiety, brain damage due to alcohol “addiction”

Over the last 2 decades a large number of studies have come out demonstrating that the withdrawal symptoms in “addicts” are due largely due to elevated serotonin and adrenaline. As such, drugs such as cyproheptadine, clonidine, propranolol, etc have been successfully used off-label for treating withdrawal symptoms. https://www.ncbi.nlm.nih.gov/pubmed/2178473 https://www.ncbi.nlm.nih.gov/pubmed/6907020 https://link.springer.com/article/10.1007/BF00421401 Now, a new study adds … Read more Blocking serotonin, adrenaline treats anxiety, brain damage due to alcohol “addiction”

Serotonin causes anhedonia…and mental illness in general

As many of my readers know, anhedonia is one of the most pernicious symptoms of most mental disorders, and is perhaps the most resistant to therapy. It also happens to be one of the main triggers of attempted suicide, based on interviews with suicide survivors. I posted some threads in the past demonstrating that chronic … Read more Serotonin causes anhedonia…and mental illness in general

Serotonin causes the startle response, and likely PTSD as well

As my readers know, I have posted quite a few threads in the past on the topic of PTSD. It is a condition that affects up to 30% of current/former military members, and is considered a condition of unknown cause and without treatment. Current treatment options consist of mostly symptom management with serotonergic (SSRI) drugs … Read more Serotonin causes the startle response, and likely PTSD as well

Chronic stress (adversity) lowers dopamine and causes mental illness

The evidence for the role of chronic stress in virtually every health condition doctors have a name for just keeps on accumulating. Unfortunately, even in this latest study the scientists keep insisting that there is some mysterious and unquantifiable difference between chronic stress “increasing risk of” and “causing” pathology. Yet, those same scientists have no … Read more Chronic stress (adversity) lowers dopamine and causes mental illness

PUFA and serotonin promote each other, and likely cause mental illness

I neat new study that draws a direct parallel between PUFA-driven inflammation, serotonin and depression. As the study demonstrated, high levels of the PUFA arachidonic acid (AA) are highly correlated with lower density (expression) of the serotonin transported (SERT, 5-HTT), and the relationship is actually causative in both directions (AA<->serotonin). This results in increased serotonin … Read more PUFA and serotonin promote each other, and likely cause mental illness

Gut serotonin (due to bacteria) is the master regulator of metabolism, insulin sensitivity, and weight

Over the last year I posted a number of studies demonstrating strong link between serotonin and chronic conditions such as obesity, insulin resistance, and even diabetes. https://www.nature.com/articles/s41366-018-0047-8 https://medicalxpress.com/news/2018-03-obesity-trigger-human-gut.html However, when those studies came out the medical authorities immediately countered with the argument that it is not serotonin that is the culprit but changes in the … Read more Gut serotonin (due to bacteria) is the master regulator of metabolism, insulin sensitivity, and weight

If current trends hold, within a decade the entire population may become autistic

Peat published a newsletter not long ago in which he presented evidence that not only are autism rates rising but the general population is starting to exhibit some signs/symptoms of the condition. I think he called the phenomenon a “generation-wide autism”. The study below alarmingly predicts that if current trends hold within the next decade … Read more If current trends hold, within a decade the entire population may become autistic

Progesterone may bind and deactivate endotoxin (LPS) directly

I made a few posts recently discussing the blocking effects of pregnenolone on TLR4 and TLR family receptors in general, and the reduction of systemic inflammation stemming from this blockade/regulation. http://haidut.me/?p=17 It is well-known that glucocorticoids and mineralocorticoids are protective against endotoxemic shock, possibly due to blocking the hypotensive and inflammatory effects of endotoxin. However, … Read more Progesterone may bind and deactivate endotoxin (LPS) directly

Serotonin excess, not dopamine deficiency, may be the cause of Parkinson

One of the most paradigm-challenging studies I have seen this year and, unsurprisingly, mainstream media is pulling all sorts of tricks to avoid naming the culprit directly. Even the press release and the study abstract are worded in a convoluted way, talking about a “serotonin dysfunction” instead of what the results of the study demonstrated … Read more Serotonin excess, not dopamine deficiency, may be the cause of Parkinson

A selective serotonin antagonist is a potent antidepressant

Fraud, fraud and nothing but fraud! I used to think it is shear stupidity, but the evidence for deliberate manipulation of public opinion and health policy is just too strong. After more than half a century of claiming that serotonin cures depression, now mainstream medicine is quietly trying to retreat from this fiasco by introducing … Read more A selective serotonin antagonist is a potent antidepressant