Serotonin antagonists as treatment for COVID-19 / SARS

A quick post to let my Twitter followers know that serotonin is implicated in viral diseases as well. I have posted in the past about the therapeutic effects of cyproheptadine and Benadryl on severe viral infections such as Ebola, HIV or even rabies. The serotonin antagonist below has already been observed to treat SARS caused … Read more Serotonin antagonists as treatment for COVID-19 / SARS

Serotonin may be a cause of hemorrhoids and tinnitus

The two conditions mentioned in the title of the post are quite pervasive among Western societies and their cause is, of course, officially labelled as unknown. While medicine claims that no treatment exists for tinnitus the only approved curative treatment for hemorrhoids is surgery and like any other surgical treatment of varicose veins, the problems … Read more Serotonin may be a cause of hemorrhoids and tinnitus

Blocking serotonin, adrenaline treats anxiety, brain damage due to alcohol “addiction”

Over the last 2 decades a large number of studies have come out demonstrating that the withdrawal symptoms in “addicts” are due largely due to elevated serotonin and adrenaline. As such, drugs such as cyproheptadine, clonidine, propranolol, etc have been successfully used off-label for treating withdrawal symptoms. https://www.ncbi.nlm.nih.gov/pubmed/2178473 https://www.ncbi.nlm.nih.gov/pubmed/6907020 https://link.springer.com/article/10.1007/BF00421401 Now, a new study adds … Read more Blocking serotonin, adrenaline treats anxiety, brain damage due to alcohol “addiction”

Serotonin causes anhedonia…and mental illness in general

As many of my readers know, anhedonia is one of the most pernicious symptoms of most mental disorders, and is perhaps the most resistant to therapy. It also happens to be one of the main triggers of attempted suicide, based on interviews with suicide survivors. I posted some threads in the past demonstrating that chronic … Read more Serotonin causes anhedonia…and mental illness in general

Serotonin causes the startle response, and likely PTSD as well

As my readers know, I have posted quite a few threads in the past on the topic of PTSD. It is a condition that affects up to 30% of current/former military members, and is considered a condition of unknown cause and without treatment. Current treatment options consist of mostly symptom management with serotonergic (SSRI) drugs … Read more Serotonin causes the startle response, and likely PTSD as well

Chronic stress (adversity) lowers dopamine and causes mental illness

The evidence for the role of chronic stress in virtually every health condition doctors have a name for just keeps on accumulating. Unfortunately, even in this latest study the scientists keep insisting that there is some mysterious and unquantifiable difference between chronic stress “increasing risk of” and “causing” pathology. Yet, those same scientists have no … Read more Chronic stress (adversity) lowers dopamine and causes mental illness

PUFA and serotonin promote each other, and likely cause mental illness

I neat new study that draws a direct parallel between PUFA-driven inflammation, serotonin and depression. As the study demonstrated, high levels of the PUFA arachidonic acid (AA) are highly correlated with lower density (expression) of the serotonin transported (SERT, 5-HTT), and the relationship is actually causative in both directions (AA<->serotonin). This results in increased serotonin … Read more PUFA and serotonin promote each other, and likely cause mental illness

Gut serotonin (due to bacteria) is the master regulator of metabolism, insulin sensitivity, and weight

Over the last year I posted a number of studies demonstrating strong link between serotonin and chronic conditions such as obesity, insulin resistance, and even diabetes. https://www.nature.com/articles/s41366-018-0047-8 https://medicalxpress.com/news/2018-03-obesity-trigger-human-gut.html However, when those studies came out the medical authorities immediately countered with the argument that it is not serotonin that is the culprit but changes in the … Read more Gut serotonin (due to bacteria) is the master regulator of metabolism, insulin sensitivity, and weight

If current trends hold, within a decade the entire population may become autistic

Peat published a newsletter not long ago in which he presented evidence that not only are autism rates rising but the general population is starting to exhibit some signs/symptoms of the condition. I think he called the phenomenon a “generation-wide autism”. The study below alarmingly predicts that if current trends hold within the next decade … Read more If current trends hold, within a decade the entire population may become autistic

Progesterone may bind and deactivate endotoxin (LPS) directly

I made a few posts recently discussing the blocking effects of pregnenolone on TLR4 and TLR family receptors in general, and the reduction of systemic inflammation stemming from this blockade/regulation. http://haidut.me/?p=17 It is well-known that glucocorticoids and mineralocorticoids are protective against endotoxemic shock, possibly due to blocking the hypotensive and inflammatory effects of endotoxin. However, … Read more Progesterone may bind and deactivate endotoxin (LPS) directly