Aspirin may replicate the benefits of fasting, while avoiding its risks

I just made a post about fasting raising risk of early death by about 30%. On the other hand, fasting has been shown to lower biomarkers of inflammation as well as increase autophagy, with at least the former being undeniably beneficial. We already know from other studies that the benefits of fasting are largely due to lower levels of endotoxin (LPS) as well as restriction of intake of specific amino acids such as tryptophan, methionine, cysteine, arginine, glutamate, etc. Thus, if one were to eat food deficient in those nutrients while also keeping the microbiome in check with charcoal, insoluble fiber, antibiotics, etc then one would not need to restrict calories. However, keeping all these rules in mind can get pretty exhausting and invariably people slip on their dietary rules. So, instead of playing Russian roulette with fasting and hoping it won’t lead to an early death, wouldn’t it be be nice if one could get those benefits of fasting but without the risks, while also not restricting calories, specific nutrients, or worrying about the microbiome? The study below presents evidence that taking aspirin daily may be such an all-in-one caloric restriction mimetic (CRM). The daily HED of the mice dose the study experimented with was about 8mg/kg, which means that taking 2 tablets (325mg each) aspirin daily should be able to replicate for most people the design of this study.

“…Based on the results described in this paper, aspirin may be classified as a CRM. Indeed, aspirin fulfills all the criteria of a CRM () as it (1) reduces protein acetylation by virtue of its ability to inhibit the acetyltransferase activity of EP300, (2) stimulates autophagic flux, and (3) has no cytotoxic activity. Caloric restriction-based strategies or periodic fasting have a favorable impact on health and longevity, both in non-human primates () and in human studies (), although studies carried out in different research centers yielded controversial results regarding CR-mediated improved survival outcomes in rhesus monkeys (). CRMs have been efficiently used to sensitize tumor cells to chemotherapy (), to treat obesity and metabolic syndrome (), and to prolong health span and lifespan (). Aspirin is known to reduce the occurrence and progression of several human cancer types (), to reverse high-fat diet-induced insulin resistance (), and to prolong lifespan in mice ().”

Author: haidut