SSRI use during pregnancy increase risk of neonatal seizures/epilepsy

So much for “safe and effective during pregnancy”…I shudder at the thought of how many women get talked into using SSRI during pregnancy without even having depression. You know, just in case they MIGHT get postpartum depression.

Serotonergic Antidepressant Use in Pregnancy and Risk for Neonatal Seizures

“…Researchers at Indiana University in Bloomington used data from the Medical Birth Register in Stockholm, Sweden, to examine the association between reported maternal use of SSRIs or SNRIs and the diagnosis of neonatal seizures or epilepsy in over 1.2 million children born from 1996 through 2013. Following the evaluation of the SSRI and SNRI use and parental epilepsy, researchers adjusted for a wide range of background factors (eg, age, education, and comorbidities) and pregnancy-specific characteristics (eg, maternal use of tobacco and use of other psychiatric medications). The study found that the children born to women with reported use of SSRIs or SNRIs during pregnancy had 41% greater risk for newborn seizures (n=1,551,906; risk ratio [RR], 1.41; 95% CI, 1.03-1.94) and 21% increased risk for being diagnosed with epilepsy during follow-up (n=1,367,087; hazard ratio [HR], 1.21; 95% CI, 1.03-1.43) compared with children who were unexposed to SSRIs or SNRIs. In this study, neonatal seizures and epilepsy were classified using International Classification of Diseases (ICD)-9 and ICD-10. Neonatal seizures were defined by at least 1 diagnosis within the first 30 days of life and epilepsy was defined by at least 1 diagnosis at any time after birth.”

Author: haidut