Keto diet (low-carb) causes liver insulin resistance, raises diabetes risk

Finally some common sense is coming out of mainstream medicine. As the study below aptly shows, eating low carb diets results in fatty liver and liver-specific insulin resistance, both of which are key components of diabetes II. In fact, the study says that eating a high-fat high-carb diet is LESS detrimental than eating high-fat, low-carb (keto) diet. The latter is often called the “Western diet” and has been ridiculed in the medical literature as the main cause of most metabolic diseases. Yet, as it turns out it is less problematic than the keto diets since it prevented the liver-centric insulin resistance. While the article does not discuss endocrine aspects that may also be involved in this pathology, other studies have already implicated cortisol.

It is a well-known fact that low-carb diets raise baseline cortisol. Despite that well-known fact that even mainstream medicine does not deny, the study on keto diets and insulin resistance somehow fails to make the connection between endocrine imbalance (high cortisol) caused by the low-carb diet and diabetes II. I am not sure what else needs to happen before doctors realize that obesity, insulin resistance, diabetes II, and even CVD are endocrine disorders driven by cortisol/estrogen/prolactin and not simply due to “eating more and moving less”. Speaking of that last cliche, I will be soon posting another thread showing that dieting is in fact deleterious and a change in attitude among medical professionals on that topic is desperately needed.

“…Ketogenic diets are low-carbohydrate, high-fat diets that have been shown to reduce weight. They change metabolism so that energy comes from fat instead of sugar. When researchers in Switzerland examined what happened to mice in the early stages of a ketogenic diet, they found that the animals showed a poorer ability to regulate blood sugar compared with similar mice on a high-fat, high-carbohydrate diet. In a paper on their work now published in the Journal of Physiology, they note that “even though [keto diet]-fed animals appear healthy in the fasted state, they exhibit decreased glucose tolerance to a greater extent than [high-fat diet]-fed animals.” The reason for this, they found, was that the livers of the keto diet-fed mice were not responding as well to insulin. This condition, which is known as insulin resistance, raises the risk of developing type 2 diabetes.”

“…However, the researchers found that the main reason for decreased glucose tolerance in the keto diet-fed mice was due to insulin resistance in the liver “rather than impaired glucose clearance and tissue glucose uptake.” Despite extensive research into the causes of insulin resistance and type 2 diabetes, they are not completely understood. One thing that scientists do know is that fat-like substances called lipids are “clearly associated with insulin resistance.” Even here, however, many questions remain, such as, “Is the link due to circulating fats or to fat buildup in tissue?”