Tuinone – Liquid Product with Thymoquinone – To Extract Knowledge from Matter

The topic of quinones probably does not need an extensive introduction in light of Ray’s extensive writings and interviews on the topic. Quinones are a cornerstone of the bioenergetic theory given their pro-metabolic nature as a result of their effects on improving mitochondrial biogenesis/function, promoting thyroid/gonadal function while restraining the stress/adrenal axis, reducing reactive oxygen species (ROS), mitigating cellular damage from a variety of exogenous (both chemical and physical) and endogenous (e.g. endotoxin/LPS, nitric oxide, PUFA metabolites and peroxdation byproducts), reducing inflammation, reducing muscle/bone/tissue catabolism, ameliorating the various biomarkers of aging, extending lifespan, etc. Ray’s articles mention numerous examples of quinones such as CoQ10, emodin, the tetracycline class of antibiotics, vitamin K, methylene blue, etc. In a few interviews he gave, Ray also mentioned another quinone naturally occurring in the seeds of Nigella sativa, or more commonly known as black cumin. The seeds of that plant contain the benzoquinone known as thymoquinone (TQ), and it is a simple molecule based on the 1,4-benzoquinone skeleton, but with two additional isopropyl groups attached to it, which makes TQ both more lipophilic and more stable.

https://en.wikipedia.org/wiki/Thymoquinone

As Ray mentioned in the interviews below, TQ exhibits a similar broad spectrum of beneficial effects as other quinones mentioned above, including potentially acting as a thyroid mimetic, which is a very rare property for a naturally occurring molecule as agonists of the thyroid receptor in nature (outside the mammalian body) are very rare.

https://lowtoxinforum.com/threads/thymoquinone-black-cumin-peat-mentioned-in-interview.6935/post-84622

“…RP: Recently people are talking about an Asian herb, I think one of the names is Black cumin, but it contains thymol quinone. And the quinones are, I think, the essential; model of the protective pro-oxidant stabilising chemical, and thymol quinone is considered to be a very powerful anti-inflammatory. And I suspect that it will turn out to be acting against excess nitric oxide.”

Below are several more studies and individual reports discussing specifically the pro-thyroid effects of TQ, in both humans and animals. It is worth noting that most of these studies used powder made from grinding the black cumin seeds, which results in a powder that likely contains strong metabolic and digestive inhibitors in addition to TQ. As Ray has repeatedly mentioned, seeds of plants are likely to contain the most potent toxins because the plant is trying to protect the seed from being consumed/digested by animals or destroyed by pathogens. As such, using black cumin powder (or even oil extracted from the seeds) may have a less-pronounced pro-thyroid effects compared to pure TQ, since the pro-thyroid effects of TQ would be competing against the anti-thyroid and/or toxic effects of the other chemicals in the seed the plant deposited there as natural seed defenses.

https://lowtoxinforum.com/threads/black-seeds-raised-my-temperature-more-than-dessicated-thyroid-ever-has.36652/

https://lowtoxinforum.com/threads/thymoquinone-black-cumin-peat-mentioned-in-interview.6935/post-583246

http://ijrar.org/papers/IJRAR1944176.pdf

https://www.researchgate.net/publication/310468405_The_effects_of_Nigella_sativa_on_thyroid_function_serum_Vascular_Endothelial_Growth_Factor_VEGF_-_1_Nesfatin-1_and_anthropometric_features_in_patients_with_Hashimoto’s_thyroiditis_A_randomized_control

https://www.researchgate.net/publication/297750663_Nigella_Sativa_treatment_and_serum_concentrations_of_thyroid_hormones_transforming_growth_factor_b_TGF-b_and_interleukin_23_IL-23_in_patients_with_Hashimoto’s_Thyroiditis

https://m.scirp.org/papers/44133

https://www.researchgate.net/publication/281787377_Can_nigella_sativa_oil_nso_reverse_hypothyroid_status_induced_by_PTU_in_rat_biochemical_and_histological_studies

https://www.researchgate.net/publication/289454887_Effects_of_Nigella_sativa_L_on_serum_concentrations_of_thyroid_hormones_thyroid_stimulating_hormone_and_glucose_in_alloxan-induced_diabetic_rabbits

http://www.jocms.org/index.php/jcms/article/view/75

https://www.researchgate.net/publication/268152260_THE_PROTECTIVE_ROLE_OF_NIGELLA_SATIVA_OIL_NSO_AGAINST_THYROID_ULTRASTRUCTURAL_CHANGES_INDUCED_BY_EXPOSURE_TO_DI_2-ETHYLHEXYL_PHTHALATE_DEHP

The studies on pro-thyroid effects are, of course, a small portion of all the studies conducted with TQ. Currently, PubMed lists 2,300+ published studies on TQ going all the way back to the early 1960s. Those studies cover a number of different health areas such as cancer, metabolic (in the allopathic medical sense) conditions, cardiovascular/pulmonary conditions, acute/chronic inflammation and allergy-related conditions, bone/dental conditions, neurological/mental conditions, gastrointestinal tract (GI) / hepatic / renal conditions, infection diseases, etc.

In light of the extensive peer-reviewed scientific evidence, spanning multiple decades, examining the numerous health effects ot TQ, we decided to release it as a liquid product, which contains only the pure TQ molecule, without any other residues such as toxins and/or metabolic inhibitors, as well as PUFA and its peroxidation byproducts found in black cumin seed powder or oils.

The units listed on the label are just for measurement purposes. They do not indicate suggested or optimal dose.

NOTE: The liquid in the product has an intense odor reminiscent of oregano or (black) cumin.

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Tuinone is a liquid product containing pure thymoquinone (TQ). The TQ molecule has been the subject of extensive research going back to at least the 1960s. Black cumin seeds/oils are also used in folk medicine for a very wide spectrum of conditions in many Middle Eastern and South Asian countries, including conditions related to underactive (hypo) thyroid gland states caused by a variety of physical and chemical assaults or “autoimmune” states such as Hashimoto thyroiditis.

It can be bought from the www.idealabsdc.com link.

Drops per container: about 750
Each drop contains the following ingredients:

Thymoquinone (CAS 490-91-5) 2mg

Other ingredients: add product to shopping cart to see info

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References:

1. Cancer

2. Metabolic

https://pubmed.ncbi.nlm.nih.gov/26134064/
https://pubmed.ncbi.nlm.nih.gov/29080612/
https://pubmed.ncbi.nlm.nih.gov/26544518/
https://pubmed.ncbi.nlm.nih.gov/30186162/
https://pubmed.ncbi.nlm.nih.gov/29421519/
https://pubmed.ncbi.nlm.nih.gov/30510626/
https://pubmed.ncbi.nlm.nih.gov/37568105/
https://pubmed.ncbi.nlm.nih.gov/40539260/
https://pubmed.ncbi.nlm.nih.gov/36104839/
https://pubmed.ncbi.nlm.nih.gov/38304804/
https://pubmed.ncbi.nlm.nih.gov/38629092/

3. Cardiovascular/Pulmonary

4. Inflammation/Allergy

5. Osteo/Dental

https://pubmed.ncbi.nlm.nih.gov/33322636/
https://pubmed.ncbi.nlm.nih.gov/38758543/
https://pubmed.ncbi.nlm.nih.gov/36143470/
https://pubmed.ncbi.nlm.nih.gov/36354542/
https://pubmed.ncbi.nlm.nih.gov/39464544/
https://pubmed.ncbi.nlm.nih.gov/36345183/
https://pubmed.ncbi.nlm.nih.gov/35306780/

6. Neurological/Mental

7. Gastrointestinal/Hepatic/Renal

8. Infections (first 200 URLs)

Tuinone – Liquid Product with Thymoquinone

1. Cancer

2. Metabolic

3. Cardiovascular/Pulmonary

4. Inflammation/Allergy

5. Osteo/Dental

6. Neurological/Mental

7. Gastrointestinal/Hepatic/Renal

8. Infections (first 200 URLs)

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