Yet another condition of “mysterious” origin turns out to be nothing but energetic deficiency in disguise. Namely, psoriasis – a common “autoimmune” condition – seems to be exacerbated by vitamin B2 deficiency and ameliorated by sufficient levels of that vitamin. Since the sole known role of vitamin B2 is metabolic/bioenergetic, this leaves little doubt that psoriasis, and perhaps all other “autoimmune” conditions, are amenable to bioenergetic therapy. Vitamin B2 is a precursor to the crucial metabolic co-factor flavine adenine dinucletodie (FAD), without which electron transport chain (ETC) Complex II cannot work properly. In an event of FAD deficiency (due to vitamin B2 deficiency) the functional block at ETC Complex II results in a buildup of free electrons, which then proceed to form a so-called “reverse electron flow” (REF), which is responsible for the generation of 95%+ of reactive oxygen species (ROS). The latter have a known role in virtually all chronic conditions, and have already been implicated specifically in “autoimmune” diseases. Another very important co-factor precursor is niacinamide (vitamin B3), which is used by the body to form the co-factor NAD+. The latter is responsible for about 80% of the ATP generated through the OXPHOS pathway, with the other 20% being due to the work of FAD. This fact suggests that a combination of niacinamide and riboflavin may be a viable treatment of all “autoimmune” conditions and there are already multiple studies demonstrating benefit from niacinamide supplementation in multiple sclerosis (MS), Lupus, rheumatoid arthritis (RA), inflammatory bowel disease (IBD), etc.
https://onlinelibrary.wiley.com/doi/10.1111/exd.70106
https://www.healthcentral.com/news/psoriasis/vitamin-b2-riboflavin-and-psoriasis
“…The study, published in Experimental Dermatology, points to vitamin B2 as a potential ally in calming inflammation and reducing flare-ups. Scientists at the China-Japan Friendship Hospital in Beijing, China, came to that conclusion after reviewing the diets of more than 13,000 adults with and without psoriasis. They noticed people who consumed more riboflavin were less likely to have the condition—especially when they looked at individuals over the age of 40. Then they zoomed in. Using transcriptome analysis, which looks at gene expression, the researchers examined skin cells and observed that low riboflavin levels triggered inflammation. When the vitamin was reintroduced, the stress response lessened, and the inflammation calmed down. Skin cells with psoriasis appeared to absorb even more riboflavin, leading researchers to believe the body uses the B vitamin to heal PsO-damaged skin and protect against more damage.”
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