This was a meta-study, so a single optimal dose for all mentioned conditions is probably not known at this time. However, this is one of the few studies that suggests a “simple” vitamin known as nothing more than an “antioxidant” to modern medicine can provide benefit in such a diverse set of bone conditions. Considering the known anti-estrogenic effects of vitamin E, the study does raise serious questions in regards to the mainstream medicine claims that estrogen is bone-protective and that that estrogenic HRT can treat all of the conditions mentioned below.
https://doi.org/10.1007/s43465-025-01426-1
“…The key findings of the study were:
• 19 manuscripts were selected for the review. Vitamin E is utilised in diverse forms in orthopaedic patients: administered systemically, intraarticularly or locally.
• Systemically-administered vitamin E can mitigate osteoarthritis progression through strengthening of adjoining musculature, gene regulation, protection of subchondral vasculature, and anti-inflammatory properties.
• Vitamin E incorporation has been demonstrated to improve the wear characteristics of highly crosslinked polyethylene and metal alloys in arthroplasty through its antioxidant and osteointegrative abilities.
• Antioxidant vitamin E has been shown to mitigate postoperative arthrofibrosis and septic loosening. Vitamin E can positively influence late callus formation during secondary fracture healing.
• Through its effects on osteoblastic cells, proinflammatory cytokines, growth factors, antioxidant mechanism, hormones and micro-RNA, systemic vitamin E administration can meliorate osteoporosis and mitigate fractures.
The authors concluded – “There is emerging evidence regarding the promising roles of vitamin E in diverse orthopaedic conditions such as osteoarthritis, osteoporosis, fracture healing, osteomyelitis and arthroplasty. These actions of vitamin E are attributed to its antioxidant, anti-infl ammatory and immunomodulatory functions. Large-scale clinical trials are needed to ascertain its safety, effective administrative dosage and future prospects in the realm of orthopaedic surgery.”
