It looks like we can add vitamin E to the list of remedies against endotoxin/LPS, at least when it comes to muscle health/strength. Endotoxin/LPS is well-known to induce systemic inflammation and one of the core symptoms of systemic inflammation is muscle weakness, which eventually progresses into muscle loss (sarcopenia) if the endotoxin assault continues sufficiently long. There are virtually no known remedies for inflammation induced weakness, aside from aspirin and anabolic steroids, the latter of which has significant side effects. The study below demonstrates that vitamin E (alpha-tocopherol specifically) may be one of the main endogenous protective factors against systemic inflammation induced by endotoxin and the resulting myopathies. The benefits of vitamin E in this case cannot be explained with its antioxidant effects, which suggests that its role as a COX/LOX inhibitor is probably the main mechanism of action.
https://pubmed.ncbi.nlm.nih.gov/38141774/
“…αT concentrations in the liver, heart, and adipose tissue of WT mice were higher than Ttpa-/- mice. Although αT was detected in the brain, muscle, and serum of WT mice, it was undetectable in these tissues of Ttpa-/- mice. Cerebellar and serum concentrations of IL-6 were increased in LPS-treated groups but were not significantly affected by genotype. Grip strength was reduced in LPS-treated groups, an effect that was more pronounced in Ttpa-/- mice. Systemic LPS administration caused an acute inflammatory response with a concomitant decline in grip strength, especially in Ttpa-/- mice. αT depletion appears to exacerbate reductions in grip strength brought on by systemic inflammation.”
