fibrosis

Niacinamide may treat fibrotic eye disease and prevent vision loss

by

A great new study that demonstrated nicotinamide (NAM) may also have anti-fibrotic effects in addition to its positive effects on maintaining favorable NAD/NADH ratio and redox balance. The mechanism of action of NAM was inhibition of the TGF-β pathway and overall reduction of inflammation. This anti-fibrotic effect of NAM may explain its well-known protective effects … Read more Niacinamide may treat fibrotic eye disease and prevent vision loss

Vitamin E restores cardiac health after heart attack

by

A great study that gives vitamin E a much deserved exposure in mainstream media. A few years ago, vitamin E was lambasted by the press for failing to prevent prostate cancer and heart attacks. Yet, upon a more careful look, it quickly becomes evident that those trials were handicapped from the start in a way … Read more Vitamin E restores cardiac health after heart attack

Supplementation with (long chain) saturated fats protects liver from alcohol

by

As many of my readers already know, there are a number of human studies, going back to at least the 1960s, demonstrating that supplementation with saturated fats (SFA) protects the liver from damage induced by alcohol. I fact, supplementation with SFA not only prevents alcohol-induced liver damage but actually fully reverses the fibrosis/cirrhosis induced by … Read more Supplementation with (long chain) saturated fats protects liver from alcohol

PUFA (metabolites) drive heart failure and possibly diabetes

by

Over the years I have posted a number of studies on the roles of PUFA metabolites such as prostaglandins and leukotrienes in many chronic conditions including cancer, Alzheimer, Parkinson, ALS, MS, CVD, etc. For those that are new to this issue, COX enzymes are responsible for prostaglandin synthesis while LOX enzymes are responsible for leukotriene … Read more PUFA (metabolites) drive heart failure and possibly diabetes

Daily aspirin reduces by 37% risk of fatty liver progressing into cirrhosis

by

Another great study about aspirin. What I particularly like about this study is that one of the authors is calling aspirin “a promising anti-fibrotic strategy for NAFLD”. This is the first time I have heard a doctor refer to aspirin as anti-fibrotic chemical. Peat mentioned aspirin as one of the most protective chemicals for liver … Read more Daily aspirin reduces by 37% risk of fatty liver progressing into cirrhosis

Heart failure deaths on the rise in younger US adults

by

The bad news for younger Americans just keep on coming. In addition to lethal cancers, diabetes, stroke, CVD, infertility, etc now we can add yet another “old man” disease to the list of banes inflicting the “young”. Heart failure is a condition traditionally seen in people 65 and older, and mortality from it has been … Read more Heart failure deaths on the rise in younger US adults

Epidemic of NAFLD and NASH in young people

by

Yet another sad reminder of just how much the health of the average person has declined over the last 20 years. If these trends are not reversed or at least slowed down, we may start seeing people in their 20s filing for Medicare/Medicaid due to rapidly declining health and inability to cover their health expenses … Read more Epidemic of NAFLD and NASH in young people