Keto (low-carb) diet causes heart fibrosis, blocks mitochondrial biogenesis

The bad news for the low-carb / keto community keep piling on. There are a number of posts on this blog about studies demonstrating insulin resistance, diabetes, obesity and even sarcopenia as a result of low-carb diets or their close mimetic known as intermittent fasting. Now, the study below provides the first direct evidence that … Read more

Glucocorticoids may increase inflammation in the long run

Glucocorticoids (both bioidentical and synthetic) are some of the most widely used drugs in the clinical setting, as well as in outpatient treatment for all sorts of ailments – i.e. autoimmune conditions, joint pain, post-operative inflammation, asthma, and even infectious diseases such as COVID-19. The officially improved indications for those glucocorticoid drugs continue to increase … Read more

Topical DHT therapy promotes hair growth

Despite mentioning it in another post on testosterone (T) treatment for hair loss, I thought that this study deserves its own post, just because its findings are so contradictory to the perennial dogma of “androgenic alopecia” – i.e. that androgens, and especially DHT, cause the male-pattern baldness in males and non-localized hair loss in women. … Read more

Testosterone therapy (TRT) reverses hair loss (in women)

The evidence undermining the fake/corrupt hypothesis of “androgenic alopecia” keeps accumulating. I really wish the study below was conducted in men instead of women, since its findings would have probably finally put an end to the debate as to whether androgens promote or inhibit hair growth. However, even in women the findings are quite important … Read more

Childhood stress causes mental illness in adults by blunting androgens

Yet another great study solidifying the evidence on just how detrimental early childhood stress is. It has been known for decades that childhood stress leads to early puberty, and that the latter is associated with greatly increased risk of chronic diseases later in life, as well as early death. However, mainstream medicine has always heatedly … Read more

Cortisol may drive COVID-19 mortality

The reason I decided to do a post on this study is that over the last several months, various public health authority bodies around the world have adopted “treatment protocols” for COVID-19 hospitalized patients, and virtually all such protocols contain a potent synthetic glucocorticoid such as dexamethasone. If the findings of the study below are … Read more

Stress (cortisol) as the driver of hyperglycemia in type II diabetes

To most of my readers, the title of the post may seem like something completely obvious and not deserving explanation of clarification. However, according to mainstream medicine (until now, at least) cortisol does not really have a causative role either in the development of diabetes type II or in its various manifestations such as obesity, … Read more

PUFA promote torpor / hibernation, decrease lifespan

Not many studies on this topic, but here is one that will hopefully satisfy my critics who keep complaining that there is no evidence for the anti-metabolic, pro-hibernation effects of PUFA. Apparently, PUFA is sought after by hibernating animals (but even they consume it within very tightly controlled amounts/seasons) and universally avoided by non-hibernating ones … Read more

PUFA are potent immunosuppresive agents

Just a quick post for all those PUFA/fish-oil lovers who keep sending me hate-mail about the “incredibly beneficial” omega-3, and even omega-6 (e.g. some athletes/bodybuilders tout arachidonic acid as a natural “anabolic agent”). As the study below discusses, all PUFA, but especially omega-3, are about as potent as glucocorticoids in inducing T-cell death. Modern medicine … Read more

Blocking PUFA/prostaglandins restores metabolism and reverses brain aging

The bad news for PUFA has been accumulating for decades, yet public health authorities continue to claim that type of fat is “essential”. Whatever indirect admissions of the pathological role of PUFA in both chronic and acute/infectious diseases is given to the public, is usually confined to the well-known PUFA metabolites known as prostaglandins. However, … Read more