Yet another study showing the key role of endotoxin (LPS) in “irreversible” and lethal conditions such as heart failure. It is also yet another study to suggest that there may be no such a thing as “beneficial” gut bacteria, as any strain capable of producing endotoxin likely contributes to development/progression of chronic disease, and most strains found in human guts do produce endotoxin.
“…The research is based on the idea that microbes living in the gastrointestinal tract affect heart failure by increasing the production of T cells, a type of immune cell. Researchers found mice with induced heart failure fared better if they were treated with antibiotics for five weeks, essentially sterilizing the gut. “Our lab studies how the gut talks to the heart through T cells,” said Francisco J. Carrillo-Salinas, PhD, a postdoctoral scholar at Tufts University who conducted the research. “Given that the gut is the body’s largest reservoir of T cells and microbes, by modulating the microbiota we could modulate T cell activation and changes in the heart that lead to heart failure.”
Heart failure is a condition in which the heart cannot pump enough blood to meet the body’s needs. Nearly 6 million Americans have heart failure, and about half of people diagnosed with heart failure die within five years. Carrillo-Salinas’ group has previously shown that T cells infiltrate the heart in patients with heart failure. Inflammation, which is a consequence of the immune response, also is known to play important roles in heart disease.
Among mice with induced heart failure, those that received antibiotics showed significantly better heart pumping ability and less damage to the heart tissue compared to those that did not receive antibiotics. “Because complete sterilization of the gut has proven to ameliorate some experimental models of T cell mediated diseases, our results were in agreement with our initial hypothesis,” said Carrillo-Salinas. “The fact that we see fully preserved heart function is surprising, and I am looking forward to exciting new data on what happens in the heart once different bacteria recolonize the gut.”
The results suggest that T cells are activated in the lymph nodes located nearest the heart, move into the heart and then contribute to heart failure progression by releasing signaling proteins known as cytokines and inducing the heart to become enlarged and form scar tissue. All of these changes were prevented in the mice that received antibiotics. “Understanding how the gut microbiota directly regulates the function of distant organs such as the heart will shed new light into potential new therapeutic approaches in patients recently diagnosed with heart failure to prevent progression,” said Carrillo-Salinas. “Our results demonstrate that gut microbiota depletion prevents cardiac dysfunction and set the stage for future studies that will determine which components of the microbiota are responsible for heart failure progression.”