Childhood stress causes mental illness in adults by blunting androgens

Yet another great study solidifying the evidence on just how detrimental early childhood stress is. It has been known for decades that childhood stress leads to early puberty, and that the latter is associated with greatly increased risk of chronic diseases later in life, as well as early death. However, mainstream medicine has always heatedly … Read more Childhood stress causes mental illness in adults by blunting androgens

Stress (cortisol) as the driver of hyperglycemia in type II diabetes

To most of my readers, the title of the post may seem like something completely obvious and not deserving explanation of clarification. However, according to mainstream medicine (until now, at least) cortisol does not really have a causative role either in the development of diabetes type II or in its various manifestations such as obesity, … Read more Stress (cortisol) as the driver of hyperglycemia in type II diabetes

Sugar (sucrose) lowers stress-induced cortisol

Just a quick post to give some props to the much-vilified sucrose. The study below demonstrates that sucrose consumption for just 3 days prior, blunted most of the negative effects of stress, and especially the rise in plasma cortisol. The HED of sucrose was about 4g/kg, which matches closely Peat’s recommendations that consumption of 350g-400g … Read more Sugar (sucrose) lowers stress-induced cortisol

Heart attack survivors have high stress (cortisol/adrenaline) hypersensitivity, low androgens

A very interesting study that highlights yet again the connection between chronic stress and ill systemic health, especially cardiovascular disease (CVD). The study demonstrates that people who had experienced a heart attack have dramatically higher higher cortisol and adrenaline/noradrenaline levels, combined with low levels of androgens such as testosterone and DHEA a full 6 months … Read more Heart attack survivors have high stress (cortisol/adrenaline) hypersensitivity, low androgens

Stress-driven lipid peroxidation, inflammation re-awakens dormant cancer cells

Yet another study demonstrating that stress is anything but benign or irrelevant for chronic diseases, especially for cancer. The study below demonstrates that stress-induced increases of epinephrine and norepinephrine results in increased lipolysis and a cascade of pro-carcinogenic downstream effects. Now, if the fat released as a result of the increased lipolysis was fully saturated … Read more Stress-driven lipid peroxidation, inflammation re-awakens dormant cancer cells

Sexual activity and stress levels (HPA activity) may determine longevity

The study below tried to tease out the main factors affecting the longevity of the legendary naked mole rat – the animal with longest lifespan in its genus, and the sole mammal known to be virtually immune to developing cancer. Most of the biological/biochemical findings in regards to naked mole rats have already been found … Read more Sexual activity and stress levels (HPA activity) may determine longevity

Meditation can worsen mental health, even cause clinical psychiatric issues

I have always been ambivalent in regards to meditation, mostly due to its teachings that many perceived problems are simply in “our head” and all we need to do as “treatment” is steer our thoughts in a particular direction. We are flooded with information/advice that once we master whatever technique the specific type of meditation … Read more Meditation can worsen mental health, even cause clinical psychiatric issues

Childhood stress / deprivation leads to early puberty / aging

The evidence that adult health problems have their roots in childhood or even prenatally continues to accumulate. The study below demonstrates that children who have experienced violence, trauma, deprivation or have had generally stressful childhoods not only enter puberty much earlier but are on average several years older (biologically) than their peers. While being several … Read more Childhood stress / deprivation leads to early puberty / aging

Lab animals kept under stressful conditions, thus affecting study results

Several months ago, I did a post on just how stressful the IP administration method is for lab animals. That method is considered the de-facto standard for steroid studies, yet it appears it is so stressful that it can easily produce invalid results due to the its strong effects on the HPA axis and overall … Read more Lab animals kept under stressful conditions, thus affecting study results

Low metabolism, cellular debris may cause Huntington Disease (HD)

Yet another study demonstrating the crucial role of oxidative metabolism (OXPHOS) in a chronic degenerative condition considered largely genetic in origin. Just as importantly, the study corroborates findings from other recent reports/experiments demonstrating that the presence of cellular debris in the blood stream is anything but benign. The presence of such debris is interpreted by … Read more Low metabolism, cellular debris may cause Huntington Disease (HD)