PUFA is catabolic, SFA is anti-catabolic (anabolic)

During the early days of anabolic-androgenic steroid (AAS) science, it quickly became apparent that the ability of AAS to preserve and/or increase muscle mass was related to their ability to reduce/block the expression of amino acid catabolic enzymes such as tyrosine aminotransferase (TAT). TAT is induced almost exclusively by glucocorticoids and is used clinically as … Read more PUFA is catabolic, SFA is anti-catabolic (anabolic)

Policosanol is antiviral and a potent inducer of anti-aging gene Klotho

This post is a good complement to the recent ones I did on androgens, estrogens and their opposing effects on the expression of the anti-aging gene Klotho. While I was doing research on that gene, I had a “random” thought pop up in my mind. It is well-known that some Caribbean countries have a very … Read more Policosanol is antiviral and a potent inducer of anti-aging gene Klotho

PUFA exacerbate, saturated fats (SFA) / albumin / calcium ameliorate COVID-19

A few months ago I posted about a study discussing the role of lipid peroxidation in the COVID-19 pathology. While that study did not make any statements about effects of diet on the disease course/outcome, it did suggest lipid peroxidation blockers such as vitamin E would be therapeutic. Now, we have another study that points … Read more PUFA exacerbate, saturated fats (SFA) / albumin / calcium ameliorate COVID-19

SFA / MUFA are preferentially oxidized, while PUFA are stored/accumulated

Just a quick post in response to some of the hate mail I keep getting on a daily basis in regards to the body’s discriminatory treatment of various fat types. According to various proponents of keto diets, fasting, etc the organism has no preference for one type of fat or another in terms of oxidation … Read more SFA / MUFA are preferentially oxidized, while PUFA are stored/accumulated

Cholesterol and saturated fat are anabolic; PUFA/MUFA akin to chemical castration

A pair of interesting study and a commentary in the highly respected Journals of Gerontology. Namely, higher cholesterol intake is associated with much higher lean muscle mass accrual as a result of weight lifting. Interestingly, higher protein intake was not. Even more interestingly, and much to the chagrin of the medical industry, the increased dietary … Read more Cholesterol and saturated fat are anabolic; PUFA/MUFA akin to chemical castration

Supplementation with (long chain) saturated fats protects liver from alcohol

As many of my readers already know, there are a number of human studies, going back to at least the 1960s, demonstrating that supplementation with saturated fats (SFA) protects the liver from damage induced by alcohol. I fact, supplementation with SFA not only prevents alcohol-induced liver damage but actually fully reverses the fibrosis/cirrhosis induced by … Read more Supplementation with (long chain) saturated fats protects liver from alcohol