lps

Emulsifiers found in most commercial foods cause brain tumors, hemorrhage, and stroke

by

A really interesting study that demonstrates how emulsifiers considered “benign” by the FDA/USDA and present in virtually all commercial food can actually cause quite a bit of damage to health. The study demonstrates that even a low-dose of a common commercial emulsifier Polysorbate 80 (P80) damages the mucosal barrier of the gut and increases both … Read more Emulsifiers found in most commercial foods cause brain tumors, hemorrhage, and stroke

CamphoSal – Liquid Camphoric Acid + Salol

by

As many readers know, Peat has written extensively on the benefits of antibiotics and on keeping the GI tract as free of bacteria as possible. Bacterial overgrowth in the colon alone is already a problem due to the production of endotoxin, but in hypothyroid people this bacterial overgrowth can extend into the small intestine. The … Read more CamphoSal – Liquid Camphoric Acid + Salol

Endotoxin has a G.E.L.D.I.N.G effect, causes obesity and hypogonadism

by

A very interesting study proposing that the decline in gonadal function seen in obese/diabetic men is due to chronically elevated endotoxin levels in such people. The study calls this phenomenon (G)ut (E)dotoxin (L)eading to a (D)ecline (I)n (G)onadal function (GELDING) due to the remarkable similarities in the phenotypes caused by castration and chronic endotoxemia. While … Read more Endotoxin has a G.E.L.D.I.N.G effect, causes obesity and hypogonadism

Supplementation with (long chain) saturated fats protects liver from alcohol

by

As many of my readers already know, there are a number of human studies, going back to at least the 1960s, demonstrating that supplementation with saturated fats (SFA) protects the liver from damage induced by alcohol. I fact, supplementation with SFA not only prevents alcohol-induced liver damage but actually fully reverses the fibrosis/cirrhosis induced by … Read more Supplementation with (long chain) saturated fats protects liver from alcohol

Allopregnanolone as a treatment of Alzheimer Disease (AD)

by

It looks like the recent FDA approval of allopregnanolone (ALLO) for postpartum depression may open the floodgates to ton of new research with this steroid, as well as with its reliable precursors such as pregnenolone and progesterone. I posted several studies in the past demonstrating that pregnenolone, progesterone and ALLO are all endotoxin antagonists and … Read more Allopregnanolone as a treatment of Alzheimer Disease (AD)

Chronic nerve pain may be caused by endotoxin, commercial food, and pharma drugs

by

I posted a few threads last year demonstrating that some cases of chronic nerve pain may be caused by a side effects of opioids – activation of TLR4. However, that study only looked at why certain patients using opioids for severe pain go on to develop chronic pain of phantom origin. As such, the study … Read more Chronic nerve pain may be caused by endotoxin, commercial food, and pharma drugs

Progesterone may bind and deactivate endotoxin (LPS) directly

by

I made a few posts recently discussing the blocking effects of pregnenolone on TLR4 and TLR family receptors in general, and the reduction of systemic inflammation stemming from this blockade/regulation. http://haidut.me/?p=17 It is well-known that glucocorticoids and mineralocorticoids are protective against endotoxemic shock, possibly due to blocking the hypotensive and inflammatory effects of endotoxin. However, … Read more Progesterone may bind and deactivate endotoxin (LPS) directly

Niacinamide may improve symptoms of ALS

by

Just over a week ago I posted a thread on ALS being linked to increased fatty acid oxidation (FAO) and as such a decreased glucose availability/oxidation. http://haidut.me/?p=239 Now, the study below further corroborates this FAO-disease association by demonstrating a causative link between a change in the microbiome and the development/progression of ALS. The change in … Read more Niacinamide may improve symptoms of ALS

MS Tied To Glucose Deficiency Due To Endotoxin And Fat, Extra Glucose May Treat It

by

Just a few days ago I posted the groundbreaking study on metabolic derangement in ALS – i.e. it is a diseased characterized by increased FAO, which wastes glucose. Simply increasing dietary glucose was able to greatly restrain the pathology. Well, hot on the heels of that study is the study below, which found very similar … Read more MS Tied To Glucose Deficiency Due To Endotoxin And Fat, Extra Glucose May Treat It

Sterilizing the gut may treat heart failure

by

Yet another study showing the key role of endotoxin (LPS) in “irreversible” and lethal conditions such as heart failure. It is also yet another study to suggest that there may be no such a thing as “beneficial” gut bacteria, as any strain capable of producing endotoxin likely contributes to development/progression of chronic disease, and most … Read more Sterilizing the gut may treat heart failure