To Extract Knowledge from Matter
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About 2 years ago I posted about a study that suggested pregnenolone may relieve low-back pain in humans. At the time, a bigger human clinical trial was planned and the results of that trial were just released. Pregnenolone, slowly titrated to reach doses of 500mg/day, was found to be safe and effective for low-back pain … Read more Pregnenolone safe and effective in big human trial for back pain
Yet another study demonstrating the crucial role of the endotoxin/LPS (and its sentinel receptors) in a chronic idiopathic condition – in this case asthma. The cause of asthma is, as usual, officially claimed to be unknown but it is known that asthma can be exacerbated by environmental pollution (even though a causal relationship is flatly … Read more Asthma is driven by endotoxin and its receptors (TLR4, TLR5)
A great new study that is not afraid to point out the paradox between mainstream medicine’s claims of beneficial effects of cortisol and the reality of “autoimmune” conditions more often than not being associated with elevated levels of CRH, ACTH and cortisol. The role of CRH as a causative factor in a number of chronic … Read more Stress (cortisol) can cause ANY autoimmune condition by disrupting gut barrier
Traumatic brain injury (TBI) is a pathology affecting most often military staff exposed to explosions, competitive athletes in contact sports (especially in the NFL), accident victims, etc but lately has also been shown to occur in more benign situations such as repeated low-grade impacts such as playing soccer on a regular basis and heading the … Read more Epilepsy, as a result of brain injury (TBI), is caused by endotoxin receptor (TLR4)
A really interesting study that demonstrates how emulsifiers considered “benign” by the FDA/USDA and present in virtually all commercial food can actually cause quite a bit of damage to health. The study demonstrates that even a low-dose of a common commercial emulsifier Polysorbate 80 (P80) damages the mucosal barrier of the gut and increases both … Read more Emulsifiers found in most commercial foods cause brain tumors, hemorrhage, and stroke
As many readers know, Peat has written extensively on the benefits of antibiotics and on keeping the GI tract as free of bacteria as possible. Bacterial overgrowth in the colon alone is already a problem due to the production of endotoxin, but in hypothyroid people this bacterial overgrowth can extend into the small intestine. The … Read more CamphoSal – Liquid Camphoric Acid + Salol
A very interesting study proposing that the decline in gonadal function seen in obese/diabetic men is due to chronically elevated endotoxin levels in such people. The study calls this phenomenon (G)ut (E)dotoxin (L)eading to a (D)ecline (I)n (G)onadal function (GELDING) due to the remarkable similarities in the phenotypes caused by castration and chronic endotoxemia. While … Read more Endotoxin has a G.E.L.D.I.N.G effect, causes obesity and hypogonadism
As many of my readers already know, there are a number of human studies, going back to at least the 1960s, demonstrating that supplementation with saturated fats (SFA) protects the liver from damage induced by alcohol. I fact, supplementation with SFA not only prevents alcohol-induced liver damage but actually fully reverses the fibrosis/cirrhosis induced by … Read more Supplementation with (long chain) saturated fats protects liver from alcohol
It looks like the recent FDA approval of allopregnanolone (ALLO) for postpartum depression may open the floodgates to ton of new research with this steroid, as well as with its reliable precursors such as pregnenolone and progesterone. I posted several studies in the past demonstrating that pregnenolone, progesterone and ALLO are all endotoxin antagonists and … Read more Allopregnanolone as a treatment of Alzheimer Disease (AD)
I posted a few threads last year demonstrating that some cases of chronic nerve pain may be caused by a side effects of opioids – activation of TLR4. However, that study only looked at why certain patients using opioids for severe pain go on to develop chronic pain of phantom origin. As such, the study … Read more Chronic nerve pain may be caused by endotoxin, commercial food, and pharma drugs