How lipolysis may damage organs such as the heart

It is well-known in endocrinology, and especially among doctors specializing in diabetes, that excessive lipolysis is highly detrimental not only for the overall progression of metabolic diseases like diabetes, but also for most of the organs of the patient. Lipolysis is known to be elevated in most obese people, and especially in people with diabetes. … Read more

Mitochondrial debris leaking in bloodstream may cause autoimmune disease

This has been a recurring topic in my posts, and I am glad to see that more and more scientists are starting to take seriously the idea that chronic stress may be the ultimate cause of most/all “autoimmune” conditions. The whole idea of the immune system suddenly starting to attack an organ/tissue is quite bizarre … Read more

Low metabolism, cellular debris may cause Huntington Disease (HD)

Yet another study demonstrating the crucial role of oxidative metabolism (OXPHOS) in a chronic degenerative condition considered largely genetic in origin. Just as importantly, the study corroborates findings from other recent reports/experiments demonstrating that the presence of cellular debris in the blood stream is anything but benign. The presence of such debris is interpreted by … Read more

Simply diluting “old blood” has the same anti-aging effects as parabiosis

The topic of using blood from young people to stave off aging and disease is hardly new. Rumors have been circulating for centuries that the old and rich use all kinds of gruesome methods to acquire blood from young people and use that blood for all sorts of bizarre rejuvenating procedures. There is even a … Read more

How chronic stress (cortisol) causes disease

Back in 2018 I did a post on a neat study that demonstrated how the presence of cellular (mitochondrial) fragments in the blood stream acts identically to the pituitary hormone ACTH and as such activates the HPA axis. The more cellular fragments are in the bloodstream the more intense the stress response from the adrenals. … Read more