Tag: lactate
The GLP-1 weight loss drugs may trigger a life-threatening brain condition by depleting vitamin B1
Deficiency of vitamin B1 is rare in the modern world, but still occurs in regions where malnutrition…
A shift from oxidative toward anaerobic metabolism increases nitric oxide (NO) and lactate and drives migraines
Ray mentioned the topic of migraines many times in his articles. He implicated estrogen, serotonin, NO and…
Glutathione (GSH) drives cancer metastasis by promoting cell survival under hypoxia
In many of the podcasts I have done over the years, as well as many of my…
ROS (elevated by fat oxidation) drive immune dysfunction in cancer; vitamin E may help
Yet another study demonstrating that metabolism controls an aspect of physiology so far considered largely independent of…
Top diabetes drug Metformin causes muscle atrophy by activating AMPK/myostatin
The drug metformin probably needs no introduction here. It is one of the oldest and most widely…
Lactate drives cancer resistance to chemotherapy, reducing lactate is therapeutic
Over the last 5-6 years, a number of high profile articles (many of them, including the new…
Lactate damages mitochondria and can cause (pulmonary) fibrosis
In the first half of the 20th century lactate had a largely negative reputation in medical circles…
Reduced availability/oxidation of glucose sufficient to cause heart failure (HF)
Yet another “mysterious” idiopathic condition turns out to be nothing but metabolic dysregulation in disguise. Also, unlike…
Even briefly elevated lactate is a “master” cause of chronic diseases
The title of the post actually does not do justice to how strongly the study authors word…
Lactate is a key driver of diabetes/obesity, by promoting inflammation
A great study, demonstrating that in diabetes (just as in cancer) the so-called Warburg Effect (aerobic glycolysis)…