Tag: lactate
Glutathione (GSH) drives cancer metastasis by promoting cell survival under hypoxia
In many of the podcasts I have done over the years, as well as many of my…
ROS (elevated by fat oxidation) drive immune dysfunction in cancer; vitamin E may help
Yet another study demonstrating that metabolism controls an aspect of physiology so far considered largely independent of…
Top diabetes drug Metformin causes muscle atrophy by activating AMPK/myostatin
The drug metformin probably needs no introduction here. It is one of the oldest and most widely…
Lactate drives cancer resistance to chemotherapy, reducing lactate is therapeutic
Over the last 5-6 years, a number of high profile articles (many of them, including the new…
Lactate damages mitochondria and can cause (pulmonary) fibrosis
In the first half of the 20th century lactate had a largely negative reputation in medical circles…
Reduced availability/oxidation of glucose sufficient to cause heart failure (HF)
Yet another “mysterious” idiopathic condition turns out to be nothing but metabolic dysregulation in disguise. Also, unlike…
Even briefly elevated lactate is a “master” cause of chronic diseases
The title of the post actually does not do justice to how strongly the study authors word…
Lactate is a key driver of diabetes/obesity, by promoting inflammation
A great study, demonstrating that in diabetes (just as in cancer) the so-called Warburg Effect (aerobic glycolysis)…
Reduced pyruvate and/or increased lactate drive heart failure
I just did a post on the role of reduced glucose metabolism, lower pyruvate/NAM/NAD and elevated lactate…
Niacinamide may treat ALS by improving energetic state
Another study sent to me by the Austrian collaborator. Once again, the energetic origin of “incurable” diseases…