Estrogen lowers T, DHT, and fertility; inhibits 5α-Reductase (5-AR)

I am posting this study below as a response to numerous angry emails I have been getting over the years. People sending me those emails just cannot accept the idea that estrogen can be detrimental for males (and females as well), and that estrogen levels are directly antagonistic to the male phenotype. This “‘male antagonism” … Read more Estrogen lowers T, DHT, and fertility; inhibits 5α-Reductase (5-AR)

Lowering DHT synthesis causes severe hypothyroidism, despite higher T levels

Just a quick post in regards to one of the most controversial steroids out there – dihydrotestosterone (DHT). Mainstream medicine has vilified this steroid for decades and has blamed a host of male and female pathologies on it – i.e. baldness, prostate enlragement (BPH), prostate cancer (PC), PCOS, diabetes, obesity, dementia, osteoporosis, etc. One of … Read more Lowering DHT synthesis causes severe hypothyroidism, despite higher T levels

Vitamin E, anabolic / catatoxic steroids, egg yolks stop soft tissue calcification and (maybe) even aging

A great series of studies performed in the 1960s, with Hans Selye spearheading most of the investigations. It is amazing how much was known about human disease and aging, and how much of that knowledge has been so thoroughly forgotten to the point that doctors nowadays have never even heard of the term “catatoxic”. One … Read more Vitamin E, anabolic / catatoxic steroids, egg yolks stop soft tissue calcification and (maybe) even aging

Pregnenolone (P5) fully prevents testicular atrophy due to steroid (ab)use or high estrogen

I often get emails from bodybuilders, athletes and others who have used or currently use steroids and want to either protect themselves while using those steroids or want to recover after long-term usage. It is well-known that most performance enhancing steroids, including plain testosterone (T) or DHT, suppress gonadal function through a negative feedback mechanism … Read more Pregnenolone (P5) fully prevents testicular atrophy due to steroid (ab)use or high estrogen

Drop in androgen levels causes Parkinson Disease (PD), DHT reverses it

Yet another study demonstrating that many of the so-called chronic, degenerative and above all “mysterious” conditions often have quite a simple cause and, potentially, treatment. There is no need for mutated genes or complex interactions of genes with environment that nobody can decipher. Chronic stress leads to metabolic and endocrine changes that alone are sufficient … Read more Drop in androgen levels causes Parkinson Disease (PD), DHT reverses it

Oral free/base (unesterified) testosterone is more effective and safer than synthetic AAS

A number of my blog readers contacted me over the last 2 weeks and urged me to write this post in response to the recent FDA approval of the first oral testosterone (T) product in the USA. The approved product will contain the testosterone ester undecanoate in the form of tablets. https://www.fda.gov/news-events/press-announcements/fda-approves-new-oral-testosterone-capsule-treatment-men-certain-forms-hypogonadism Well here is my … Read more Oral free/base (unesterified) testosterone is more effective and safer than synthetic AAS

Testosterone does NOT impair empathy in men

I am sure most readers are quite familiar with the cliche that testosterone (T) is what drives stereotypical “boy behavior” – aggressiveness, carelessness, impulsive behavior, risk taking, cheating, and of course the militaristic attitude characterized by lack of (or reduced) empathy. As I mentioned in several previous posts, most of these behaviors seem to be … Read more Testosterone does NOT impair empathy in men

The stereotypes about testosterone (T) are likely wrong

A really great study for a number of reasons. Not only does it show that the commonly cited stereotypes about T’s effects on human behavior are likely all wrong, but it also demonstrates the powerful effects the process of “pre-registering” has on study outcomes. The process of pre-registering involves the scientists submitting a priori their … Read more The stereotypes about testosterone (T) are likely wrong

High cortisol and low testosterone likely drive PTSD

As the article below states, 20%+ of service members come back with PTSD. It is a devastating mental condition that makes patients not only unable to participate meaningfully in society but often drives them to violent and homicidal/suicidal behavior. Given the roles of cortisol and serotonin in driving violent psychotic behavior, the etiology of PTSD … Read more High cortisol and low testosterone likely drive PTSD

Cheating is driven by cortisol, not testosterone

The topic of macho behavior and its apparent mediator testosterone has been studies every since steroids were discovered. The mainstream dogma states that high testosterone drives cheating behavior (especially of males) as some sort of dominance-asserting behavior of genetically superior organisms. Yet, evidence has been accumulating that cheating, similarly to addiction, is simply a desperate … Read more Cheating is driven by cortisol, not testosterone