“Reductive” stress harms cells, mitochondria protect by increasing metabolism

Finally a study that provide me with some “ammo” during my arguments with people I know who work in the medical profession. A common topic in such arguments is the mainstream medical idea that it is almost impossible to have too much antioxidants and too little oxidation. In fact, to many doctors it is excessive … Read more

Niacinamide + pyruvate may treat glaucoma (human study)

Some excellent results from a human clinical trial. Namely, a combination of 3g niacinamide and 3g (calcium) pyruvate daily demonstrated significant therapeutic effect in patients with already established glaucoma. I can’t access to actual study link on JAMA, but I suspect the mechanism of action is, again, improved bioenergetic state with niacinamide raising the NAD/NADH … Read more

Low, not high, metabolism creates oxidative stress

A hugely popular tenet of the “rate of living” theory is that the higher the metabolic rate the more reactive oxygen species (ROS) an organism produces. ROS elevation has already been implicated in a host of chronic disease including diabetes, CVD, cancer, neurological conditions and even mental health disorders. However, the explanation of higher ROS … Read more

Alcohol causes liver (and other organ) damage by lowering NAD/NADH ratio

A neat little study, which demonstrates once again the crucial role of energy and optimal redox status in a public health issue that has now reached catastrophic proportions. Namely, alcohol-related morbidity and mortality. Those have always been an issue in any developed country but since the start of the “pandemic” have exacerbated dramatically. As most … Read more

Vitamin K may treat leukemia

Another great study demonstrating both the therapeutic potential of vitamins as well as the metabolic/redox nature of cancer. As I mentioned in some of my podcasts, vitamin K2 (MK-4) is currently in clinical trials for treating/preventing a number of different cancers, especially liver cancer (HCC) and the so-called myelodisplastic conditions which spans all blood cancers … Read more