Endotoxin (LPS) as a cause of systemic inflammation seen in obesity

Yet another study implicating the great villain of systemic health – endotoxin / LPS. It is well-known that most people with obesity have high levels of inflammatory biomarkers both in their tissues and bloodstream. The study below demonstrates that the inflammation seen in adipose tissue of obese organisms is likely due to endotoxin / LPS. … Read more Endotoxin (LPS) as a cause of systemic inflammation seen in obesity

Even “non-carcinogenic” estrogens can cause cancer

I know, the title is a “paradox”, but this is truly what the article discusses. By now, we already know that the word “paradox” in science is just a euphemism for idotism and/or fraud. Apparently, mainstream medicine has managed to convinced the public somehow that there are carcinogenic and non-carcinogenic estrogens. An example of the … Read more Even “non-carcinogenic” estrogens can cause cancer

Stress-driven lipid peroxidation, inflammation re-awakens dormant cancer cells

Yet another study demonstrating that stress is anything but benign or irrelevant for chronic diseases, especially for cancer. The study below demonstrates that stress-induced increases of epinephrine and norepinephrine results in increased lipolysis and a cascade of pro-carcinogenic downstream effects. Now, if the fat released as a result of the increased lipolysis was fully saturated … Read more Stress-driven lipid peroxidation, inflammation re-awakens dormant cancer cells

Glycine (and leucine) can treat fatty liver (NAFLD and NASH)

A great new study that demonstrates the strong protective effects of glycine, alone or in combination with leucine, on preventing/treating various forms of fatty liver disease, as well as the obesity that often accompanies these conditions. One of the strong points of the study is that it also established a minimum daily dosage needed to … Read more Glycine (and leucine) can treat fatty liver (NAFLD and NASH)

PUFA is catabolic, SFA is anti-catabolic (anabolic)

During the early days of anabolic-androgenic steroid (AAS) science, it quickly became apparent that the ability of AAS to preserve and/or increase muscle mass was related to their ability to reduce/block the expression of amino acid catabolic enzymes such as tyrosine aminotransferase (TAT). TAT is induced almost exclusively by glucocorticoids and is used clinically as … Read more PUFA is catabolic, SFA is anti-catabolic (anabolic)

Dietary PUFA in childhood causes diabetes and irreversible (male) infertility

A great study, which corroborates the discussion in another recent post of mine on PUFA’s role in infertility and insulin-resistance / diabetes. However, the study below found that the infertility caused by dietary PUFA exposure were NOT reversible upon discontinuation of the high-fat (both PUFA and MUFA) diet, while previous studies found that the infertility … Read more Dietary PUFA in childhood causes diabetes and irreversible (male) infertility

PUFA exacerbate, saturated fats (SFA) / albumin / calcium ameliorate COVID-19

A few months ago I posted about a study discussing the role of lipid peroxidation in the COVID-19 pathology. While that study did not make any statements about effects of diet on the disease course/outcome, it did suggest lipid peroxidation blockers such as vitamin E would be therapeutic. Now, we have another study that points … Read more PUFA exacerbate, saturated fats (SFA) / albumin / calcium ameliorate COVID-19

Dietary PUFA causes (reversible) male infertility and androgen deficiency

An amazing study, which should serves as a causing to the nuts-and-seeds crowd precisely because it used exactly such a diet to produce these highly negative effects on male fertility. Come to think of it, it is common knowledge in many cultures around the world that seeds and seed extracts are often used as male … Read more Dietary PUFA causes (reversible) male infertility and androgen deficiency

Alzheimer Disease (AD) linked to PUFA accumulation in brain

So much for the “beneficial” effects of PUFA. What makes this study particularly interesting is that it calls into question a favorite defensive maneuver of clinical nutritionists. Namely, when challenged about the known inflammatory effects of omega-6 fatty acids, most medical professionals make a desperate claim that omega-3 fatty acids are actually protective and we … Read more Alzheimer Disease (AD) linked to PUFA accumulation in brain

PUFA are toxic/carcinogenic, and that has been known for decades

Quite a statement in that title but apparently that is what the current state of knowledge is, if one cares to dig a bit under the surface of lies/deception spread by public health authorities and even primary care doctors. Apparently, in some circles, the effect of PUFA on the human brain is known to rival … Read more PUFA are toxic/carcinogenic, and that has been known for decades