Endotoxin (LPS) as a cause of systemic inflammation seen in obesity

Yet another study implicating the great villain of systemic health – endotoxin / LPS. It is well-known that most people with obesity have high levels of inflammatory biomarkers both in their tissues and bloodstream. The study below demonstrates that the inflammation seen in adipose tissue of obese organisms is likely due to endotoxin / LPS. … Read more Endotoxin (LPS) as a cause of systemic inflammation seen in obesity

Glycine (and leucine) can treat fatty liver (NAFLD and NASH)

A great new study that demonstrates the strong protective effects of glycine, alone or in combination with leucine, on preventing/treating various forms of fatty liver disease, as well as the obesity that often accompanies these conditions. One of the strong points of the study is that it also established a minimum daily dosage needed to … Read more Glycine (and leucine) can treat fatty liver (NAFLD and NASH)

Obesity “paradox” strikes again – protection against COVID-19

I suspect this one will not go down will with the “lean is always good” crowd, which consists predominantly of members of the medical profession. Aside from all the health risks of obesity for pretty much any chronic disease, the news over the last 6 months have been replete with warning from all kinds of … Read more Obesity “paradox” strikes again – protection against COVID-19

Dietary fat, not carbs or protein, makes people fat

The study below adds some evidence to the debate that is has been raging for decades – i.e. just what dietary component contributes the most to weight gain. The current favorite “villain” of clinical nutrition are carbohydrates, especially their easily digestible form such as sucrose, fructose, glucose, lactose, etc. The public space is littered with … Read more Dietary fat, not carbs or protein, makes people fat

Levothyroxine (T4) monotherapy often ineffective for hypothyroidism

As most of my readers know, the currently approved therapy for hypothyroidism is levothyroxine (T4). While technically T3 and combined T4/T3 therapy are also approved by FDA, the former is only used in severe cases of myxedema and the latter is considered obsolete and a remnant of the days when the use of natural dessicated … Read more Levothyroxine (T4) monotherapy often ineffective for hypothyroidism

PUFA makes girls fat / lazy / diabetic and exercise futile

Just a few minutes ago I made a post about PUFA (from nuts) increasing risk of diabetes. I just came across another very similar study below. It found that PUFA consumption, in both mice and humans, makes them fat and highly sedentary while also increasing their diabetes risk. MUFA and SFA had no such effects … Read more PUFA makes girls fat / lazy / diabetic and exercise futile

PUFA may drive obesity, insulin resistance, liver issues in diabetes II patients

Yet another study where the message is clear – there is nothing “essential” about the PUFA we are bombarded with from all directions be that diet, medical interventions, household products, etc. What makes this study particularly relevant is that PUFA ingestion actually is promoted as one of the healthiest ways to keep weight at bay, … Read more PUFA may drive obesity, insulin resistance, liver issues in diabetes II patients

High levels of DHT may reduce diabetes risk

The title says it all, as the study is quite clear. DHT “…was most consistently associated with a lower level of insulin resistance and lower risk of incident diabetes” in the words of the study’s lead author. The current darling of “aging/obese male” treatments – testosterone (T) – was not associated with lower insulin resistance … Read more High levels of DHT may reduce diabetes risk

Vitamin D Reduces Blood Sugar And Body Fat In Obese Women

A neat study, albeit lasting much longer (about 1.5 years) than most other intervention studied with vitamin D. What makes this study particularly interesting is that it only used high doses vitamin D (60,000 IU once weekly) initially until blood levels rose into the normal range. It did not seek to achieve a specific target … Read more Vitamin D Reduces Blood Sugar And Body Fat In Obese Women

Pre-natal Viagra use causes offspring hypertension and maternal diabesity

The study looks weird at first glance – why would pregnant women take Viagra? After all, it is a drug initially developed for treating hypertension and erectile dysfunction (ED) in men. Well, the same misguided idea of using nitric oxide (NO) promoting drugs like Viagra to induce vasodilation has now been applied to the field … Read more Pre-natal Viagra use causes offspring hypertension and maternal diabesity