Tag: lactate
Lactate drives cancer resistance to chemotherapy, reducing lactate is therapeutic
Over the last 5-6 years, a number of high profile articles (many of them, including the new…
Lactate damages mitochondria and can cause (pulmonary) fibrosis
In the first half of the 20th century lactate had a largely negative reputation in medical circles…
Reduced availability/oxidation of glucose sufficient to cause heart failure (HF)
Yet another “mysterious” idiopathic condition turns out to be nothing but metabolic dysregulation in disguise. Also, unlike…
Even briefly elevated lactate is a “master” cause of chronic diseases
The title of the post actually does not do justice to how strongly the study authors word…
Lactate is a key driver of diabetes/obesity, by promoting inflammation
A great study, demonstrating that in diabetes (just as in cancer) the so-called Warburg Effect (aerobic glycolysis)…
Reduced pyruvate and/or increased lactate drive heart failure
I just did a post on the role of reduced glucose metabolism, lower pyruvate/NAM/NAD and elevated lactate…
Niacinamide may treat ALS by improving energetic state
Another study sent to me by the Austrian collaborator. Once again, the energetic origin of “incurable” diseases…
Giving COVID-19 patients pure oxygen (O2) may be brain-toxic
The current coronavirus epidemic is bringing a number of pervasive but concealed issue to the forefront. One…
Lactate is an oncometabolite (promotes cancer), no genes/mutations needed
It has now been more than 5 years since a seminal post/discussion on Reddit raised the question…
Acidosis (Warburg Effect) drives cancer through increased fat oxidation (Randle Cycle)
The evidence continues to pile on that naming the (in)famous observation made by Otto Warburg in regards…