How chronic stress (cortisol) causes disease

Back in 2018 I did a post on a neat study that demonstrated how the presence of cellular (mitochondrial) fragments in the blood stream acts identically to the pituitary hormone ACTH and as such activates the HPA axis. The more cellular fragments are in the bloodstream the more intense the stress response from the adrenals. … Read more How chronic stress (cortisol) causes disease

Elevated ESR and hCG levels are strong predictors of impending cancer diagnosis

I am posting this study for two reasons. One of them is to corroborate a statement from Peat on the role of inflammation in cancer and the diagnostic value of “non-specific” (as the medical industry likes to call them) inflammatory biomarkers such as erythrocyte sedimentation rate (ESR). https://en.wikipedia.org/wiki/Erythrocyte_sedimentation_rate http://raypeat.com/articles/aging/bleeding-clotting-cancer.shtml “…It is commonly known that the … Read more Elevated ESR and hCG levels are strong predictors of impending cancer diagnosis

CamphoSal – Liquid Camphoric Acid + Salol

As many readers know, Peat has written extensively on the benefits of antibiotics and on keeping the GI tract as free of bacteria as possible. Bacterial overgrowth in the colon alone is already a problem due to the production of endotoxin, but in hypothyroid people this bacterial overgrowth can extend into the small intestine. The … Read more CamphoSal – Liquid Camphoric Acid + Salol

Endotoxin has a G.E.L.D.I.N.G effect, causes obesity and hypogonadism

A very interesting study proposing that the decline in gonadal function seen in obese/diabetic men is due to chronically elevated endotoxin levels in such people. The study calls this phenomenon (G)ut (E)dotoxin (L)eading to a (D)ecline (I)n (G)onadal function (GELDING) due to the remarkable similarities in the phenotypes caused by castration and chronic endotoxemia. While … Read more Endotoxin has a G.E.L.D.I.N.G effect, causes obesity and hypogonadism

PUFA and serotonin promote each other, and likely cause mental illness

I neat new study that draws a direct parallel between PUFA-driven inflammation, serotonin and depression. As the study demonstrated, high levels of the PUFA arachidonic acid (AA) are highly correlated with lower density (expression) of the serotonin transported (SERT, 5-HTT), and the relationship is actually causative in both directions (AA<->serotonin). This results in increased serotonin … Read more PUFA and serotonin promote each other, and likely cause mental illness

Vitamin E restores cardiac health after heart attack

A great study that gives vitamin E a much deserved exposure in mainstream media. A few years ago, vitamin E was lambasted by the press for failing to prevent prostate cancer and heart attacks. Yet, upon a more careful look, it quickly becomes evident that those trials were handicapped from the start in a way … Read more Vitamin E restores cardiac health after heart attack

Allopregnanolone as a treatment of Alzheimer Disease (AD)

It looks like the recent FDA approval of allopregnanolone (ALLO) for postpartum depression may open the floodgates to ton of new research with this steroid, as well as with its reliable precursors such as pregnenolone and progesterone. I posted several studies in the past demonstrating that pregnenolone, progesterone and ALLO are all endotoxin antagonists and … Read more Allopregnanolone as a treatment of Alzheimer Disease (AD)

Chronic nerve pain may be caused by endotoxin, commercial food, and pharma drugs

I posted a few threads last year demonstrating that some cases of chronic nerve pain may be caused by a side effects of opioids – activation of TLR4. However, that study only looked at why certain patients using opioids for severe pain go on to develop chronic pain of phantom origin. As such, the study … Read more Chronic nerve pain may be caused by endotoxin, commercial food, and pharma drugs

Progesterone may bind and deactivate endotoxin (LPS) directly

I made a few posts recently discussing the blocking effects of pregnenolone on TLR4 and TLR family receptors in general, and the reduction of systemic inflammation stemming from this blockade/regulation. http://haidut.me/?p=17 It is well-known that glucocorticoids and mineralocorticoids are protective against endotoxemic shock, possibly due to blocking the hypotensive and inflammatory effects of endotoxin. However, … Read more Progesterone may bind and deactivate endotoxin (LPS) directly

PUFA (metabolites) drive heart failure and possibly diabetes

Over the years I have posted a number of studies on the roles of PUFA metabolites such as prostaglandins and leukotrienes in many chronic conditions including cancer, Alzheimer, Parkinson, ALS, MS, CVD, etc. For those that are new to this issue, COX enzymes are responsible for prostaglandin synthesis while LOX enzymes are responsible for leukotriene … Read more PUFA (metabolites) drive heart failure and possibly diabetes