Glucocorticoids may increase inflammation in the long run

Glucocorticoids (both bioidentical and synthetic) are some of the most widely used drugs in the clinical setting, as well as in outpatient treatment for all sorts of ailments – i.e. autoimmune conditions, joint pain, post-operative inflammation, asthma, and even infectious diseases such as COVID-19. The officially improved indications for those glucocorticoid drugs continue to increase … Read more Glucocorticoids may increase inflammation in the long run

Blocking PUFA/prostaglandins restores metabolism and reverses brain aging

The bad news for PUFA has been accumulating for decades, yet public health authorities continue to claim that type of fat is “essential”. Whatever indirect admissions of the pathological role of PUFA in both chronic and acute/infectious diseases is given to the public, is usually confined to the well-known PUFA metabolites known as prostaglandins. However, … Read more Blocking PUFA/prostaglandins restores metabolism and reverses brain aging

Endotoxin (LPS) as a cause of systemic inflammation seen in obesity

Yet another study implicating the great villain of systemic health – endotoxin / LPS. It is well-known that most people with obesity have high levels of inflammatory biomarkers both in their tissues and bloodstream. The study below demonstrates that the inflammation seen in adipose tissue of obese organisms is likely due to endotoxin / LPS. … Read more Endotoxin (LPS) as a cause of systemic inflammation seen in obesity

Stress-driven lipid peroxidation, inflammation re-awakens dormant cancer cells

Yet another study demonstrating that stress is anything but benign or irrelevant for chronic diseases, especially for cancer. The study below demonstrates that stress-induced increases of epinephrine and norepinephrine results in increased lipolysis and a cascade of pro-carcinogenic downstream effects. Now, if the fat released as a result of the increased lipolysis was fully saturated … Read more Stress-driven lipid peroxidation, inflammation re-awakens dormant cancer cells

Glycine (and leucine) can treat fatty liver (NAFLD and NASH)

A great new study that demonstrates the strong protective effects of glycine, alone or in combination with leucine, on preventing/treating various forms of fatty liver disease, as well as the obesity that often accompanies these conditions. One of the strong points of the study is that it also established a minimum daily dosage needed to … Read more Glycine (and leucine) can treat fatty liver (NAFLD and NASH)

Progesterone and allpregnanolone are protective against COVID-19

I think we will be seeing more studies on this topic, especially in light of the ongoing human studies administering progesterone or (gasp!) estrogen to men in the hopes of improving the course of their COVID-19 disease. The results from the estrogen trials are already – surprise, surprise – strongly negative, and the progesterone trials … Read more Progesterone and allpregnanolone are protective against COVID-19

Orange juice (OJ) as therapy for all coronaviruses, including SARS-CoV-2

If anybody needs a reason to convince themselves (or their family members) that drinking OJ is beneficial, maybe this new study in the context of COVID-19 will be good enough as evidence. It demonstrated that one of the main components of OJ – naringenin – is a powerful inhibitor of viral replication and it also … Read more Orange juice (OJ) as therapy for all coronaviruses, including SARS-CoV-2

Irritable bowel syndrome (IBS) caused by histamine and serotonin

I did not expect to see this statement in a mainstream science news outlet, but here it is below. I am starting to see a change in attitude towards serotonin but mainstream medicine is careful about its game. Somehow, the message about serotonin has now split into two separate, nonsensical ones – i.e. there are … Read more Irritable bowel syndrome (IBS) caused by histamine and serotonin

Activation of the endotoxin receptor (TLR4) may cause hearing loss

There is currently an epidemic of tinnitus (ear ringing) and hearing loss in virtually all developed countries. Experts are scratching heads and are failing to come up with a reason/explanation for this epidemic. As it often happens, the cause is often hidden in plain sight and if one follows the clues and the available evidence, … Read more Activation of the endotoxin receptor (TLR4) may cause hearing loss

Parkinson Disease (PD) may begin in the gut

The article below is one of at least 20 I have seen in just 2020 alone that are starting to draw attention to the metabolic/inflammatory origins of yet another neurological disease of “mysterious” origin – namely, Parkinson Disease (PD). What makes this article both interesting and infuriating is that apparently the connection between gut pathology, … Read more Parkinson Disease (PD) may begin in the gut