immune system

Adrenaline suppresses the immune system and promotes viral infections

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The timing of this study just could not have been better considering the current coronavirus epidemic. The study below demonstrates that both adrenaline and noradrenaline suppressed the immune system and both increases vulnerability to viral infection as well as increasing mortality after the infection takes hold. Conversely, blocking the adrenergic receptors increased survival rates by … Read more Adrenaline suppresses the immune system and promotes viral infections

Glucose is anabolic for thymus, opposes catabolic effects of cortisol

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As most of my readers know, cortisol is a highly catabolic steroid and one of the main agents (estrogen being another) responsible for thymus atrophy with age. These catabolic effects of cortisol can be blocked by progesterone, DHEA, pregnenolone and even DHT (but not by testosterone). The study below confirms the catabolic effects of cortisol … Read more Glucose is anabolic for thymus, opposes catabolic effects of cortisol

PUFA are immunosuppressive, fasting and protein restriction (possibly) even more so

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Several great studies, which quickly illustrate the connection between PUFA, immune system, estrogen, cortisol, cancer and the protective role vitamin A/E play as well as their likely mechanism(s) of action. As I mentioned on one of the first podcasts with Danny Roddy, the role of PUFA as immunosuppressants is actually well-known in the organ transplant … Read more PUFA are immunosuppressive, fasting and protein restriction (possibly) even more so

Reversing human aging likely possible with progesterone / DHEA

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I decided to make a post on this topic after seeing the popular press articles about a study claiming reversal of human biological (as opposed to chronological) aging. That study used human growth hormone (HGH), DHEA and metformin combination as an intervention that restores thymus health and thus reverses immunosenescence (immune system aging). It is … Read more Reversing human aging likely possible with progesterone / DHEA