Niacinamide may treat depression by improving energetic state

A very interesting study, sent to me by a collaborator who lives in Austria. It demonstrated that depression is accompanied by increased SIRT1 activity (i.e. increased fatty acid oxidation), lower ATP levels and redox balance shifted towards reduction. The study demonstrated that animals without the SIRT1 gene were highly resistant to depression and had high … Read more

Lipolysis / FFA drive breast cancer by promoting estrogen signalling

The evidence for the fat-loving nature of cancer just keeps on accumulating. During the last podcast with Danny and Ray, I mentioned that in cancer cells the enzyme fatty acid synthase (FAS) is actually part of the estrogen receptor (ER) complex. As such, anything that increases the expression/activity of one promotes the other as well. … Read more

Doxycycline akin to Meldonium / Mildronate, may cure triple-negative breast cancer

Once again, the role of excessive fat oxidation is on full display. While mainstream medicine is slowly and reluctantly admitting that cancer may in fact be a metabolic disease, it still views glucose as the primary oncogenic factor in the diet. Yet, little by little, research demonstrates that it is the excessive FAO driving cancer … Read more

Fatty acid oxidation (FAO) inhibition abrogates triple-negative breast cancer

The evidence for the role of excessive FAO in cancer keeps piling on. As many of my readers know, triple-negative breast cancer is one of the most difficult to treat and its proportion of total breast cancer cases has been steadily rising over the last 20 years. When a patient is diagnosed with such a … Read more

Pulmonary hypertension (usually fatal) likely driven by increased fat oxidation (FAO)

Most of my medically inclined readers are familiar with the “mysterious” condition pulmonary arterial hypertension (PAH). I put “mysterious” in quotes, because mainstream medicine claims that its cause is unknown, its onset is unpredictable, there is no cure, and females are affected 4-5 times more often than males. Sounds familiar? Yet, while we are being … Read more

Forcing the heart to burn glucose instead of fat may cure heart failure

One of the blockbuster studies I have seen over the last 12 months. It reads as if written by Peat himself and discusses tissue regeneration, Randle cycle, dietary control of metabolism, etc. AFAIK this is the first study brave enough to demonstrate that simply switching fuel types in an organism can have profound structural effects, … Read more

Burning more fat and less glucose leads to diabetes

I really hope the keto community and other low-carb diet afficionados are taking note of the stream of recent studies that keep demonstrating a causative link between low-carb and/or high-fat diets, fasting, chronic stress, cortisol and diabetes. The evidence at this point is indisputable, no matter how much effort the medical industry puts into trying … Read more

Arginine / glutamine depletion may treat cancer by blocking the Warburg “Effect”

As my readers have noticed, I started putting quotes around the “effect” part of the infamous observation made by Otto Warburg himself. Over the last 3-4 years, even mainstream medicine has started to publish studies acknowledging that the “effect” is very much a cause as well. In other words, acidosis is not benign and is … Read more

Inhibiting fatty acid synthesis (FAS) dramatically improves sepsis survival rate

Yet another study that points the finger straight at fat as a key factor in one of the most common causes of inpatient hospital mortality – sepsis. Sepsis is currently considered to be a condition of infectious (bacterial) etiology, driven by endotoxin. However, in light of the new findings it may be more appropriate to … Read more

MS Tied To Glucose Deficiency Due To Endotoxin And Fat, Extra Glucose May Treat It

Just a few days ago I posted the groundbreaking study on metabolic derangement in ALS – i.e. it is a diseased characterized by increased FAO, which wastes glucose. Simply increasing dietary glucose was able to greatly restrain the pathology. Well, hot on the heels of that study is the study below, which found very similar … Read more