Lipolysis / FFA drive breast cancer by promoting estrogen signalling

The evidence for the fat-loving nature of cancer just keeps on accumulating. During the last podcast with Danny and Ray, I mentioned that in cancer cells the enzyme fatty acid synthase (FAS) is actually part of the estrogen receptor (ER) complex. As such, anything that increases the expression/activity of one promotes the other as well. … Read more Lipolysis / FFA drive breast cancer by promoting estrogen signalling

Doxycycline akin to Meldonium / Mildronate, may cure triple-negative breast cancer

Once again, the role of excessive fat oxidation is on full display. While mainstream medicine is slowly and reluctantly admitting that cancer may in fact be a metabolic disease, it still views glucose as the primary oncogenic factor in the diet. Yet, little by little, research demonstrates that it is the excessive FAO driving cancer … Read more Doxycycline akin to Meldonium / Mildronate, may cure triple-negative breast cancer

Fatty acid oxidation (FAO) inhibition abrogates triple-negative breast cancer

The evidence for the role of excessive FAO in cancer keeps piling on. As many of my readers know, triple-negative breast cancer is one of the most difficult to treat and its proportion of total breast cancer cases has been steadily rising over the last 20 years. When a patient is diagnosed with such a … Read more Fatty acid oxidation (FAO) inhibition abrogates triple-negative breast cancer

Pulmonary hypertension (usually fatal) likely driven by increased fat oxidation (FAO)

Most of my medically inclined readers are familiar with the “mysterious” condition pulmonary arterial hypertension (PAH). I put “mysterious” in quotes, because mainstream medicine claims that its cause is unknown, its onset is unpredictable, there is no cure, and females are affected 4-5 times more often than males. Sounds familiar? Yet, while we are being … Read more Pulmonary hypertension (usually fatal) likely driven by increased fat oxidation (FAO)

Forcing the heart to burn glucose instead of fat may cure heart failure

One of the blockbuster studies I have seen over the last 12 months. It reads as if written by Peat himself and discusses tissue regeneration, Randle cycle, dietary control of metabolism, etc. AFAIK this is the first study brave enough to demonstrate that simply switching fuel types in an organism can have profound structural effects, … Read more Forcing the heart to burn glucose instead of fat may cure heart failure

Burning more fat and less glucose leads to diabetes

I really hope the keto community and other low-carb diet afficionados are taking note of the stream of recent studies that keep demonstrating a causative link between low-carb and/or high-fat diets, fasting, chronic stress, cortisol and diabetes. The evidence at this point is indisputable, no matter how much effort the medical industry puts into trying … Read more Burning more fat and less glucose leads to diabetes

Arginine / glutamine depletion may treat cancer by blocking the Warburg “Effect”

As my readers have noticed, I started putting quotes around the “effect” part of the infamous observation made by Otto Warburg himself. Over the last 3-4 years, even mainstream medicine has started to publish studies acknowledging that the “effect” is very much a cause as well. In other words, acidosis is not benign and is … Read more Arginine / glutamine depletion may treat cancer by blocking the Warburg “Effect”

Inhibiting fatty acid synthesis (FAS) dramatically improves sepsis survival rate

Yet another study that points the finger straight at fat as a key factor in one of the most common causes of inpatient hospital mortality – sepsis. Sepsis is currently considered to be a condition of infectious (bacterial) etiology, driven by endotoxin. However, in light of the new findings it may be more appropriate to … Read more Inhibiting fatty acid synthesis (FAS) dramatically improves sepsis survival rate

MS Tied To Glucose Deficiency Due To Endotoxin And Fat, Extra Glucose May Treat It

Just a few days ago I posted the groundbreaking study on metabolic derangement in ALS – i.e. it is a diseased characterized by increased FAO, which wastes glucose. Simply increasing dietary glucose was able to greatly restrain the pathology. Well, hot on the heels of that study is the study below, which found very similar … Read more MS Tied To Glucose Deficiency Due To Endotoxin And Fat, Extra Glucose May Treat It

ALS tied to increased fat oxidation (FAO), increasing glucose may treat it

I made a few posts in the past about ALS characterized by adrenal hyperactivity and suppressed gonadal function, as well as mitochondrial dysfunction and copper deficiency. Also, non-familial ALS is known to occurs 4-5 times more often in active/retired elite athletes. All of these findings strongly suggest ALS is linked to stress and dysregulated metabolism. … Read more ALS tied to increased fat oxidation (FAO), increasing glucose may treat it