Glaucoma likely a metabolic disease, treatable by pyruvate and/or niacinamide

About a year ago, a publication came out that demonstrated therapeutic effects of raising the (mitochondrial) NAD/NADH ratio in glaucoma patients. That study used niacinamide (NAM) and suggested that the “irreversible” changes in eye structure seen in glaucoma patients are in fact nothing more than a downstream effect of metabolic (OXPHOS) disturbances. Now, a new … Read more Glaucoma likely a metabolic disease, treatable by pyruvate and/or niacinamide

Niacinamide may treat fibrotic eye disease and prevent vision loss

A great new study that demonstrated nicotinamide (NAM) may also have anti-fibrotic effects in addition to its positive effects on maintaining favorable NAD/NADH ratio and redox balance. The mechanism of action of NAM was inhibition of the TGF-β pathway and overall reduction of inflammation. This anti-fibrotic effect of NAM may explain its well-known protective effects … Read more Niacinamide may treat fibrotic eye disease and prevent vision loss