DHT is an estrogen (receptor) antagonist

A neat little study, and in-vivo at that, which demonstrates that DHT is a direct estrogen receptor (ER) antagonist. According to the study, so are testosterone, nandrolone and a few other steroids with demonstrated therapeutic effects on ER-positive breast cancer (BC). However, all of the other steroids mentioned by the study are aromatizable and as … Read more DHT is an estrogen (receptor) antagonist

Androgens boost, estrogen inhibits, anti-aging gene Klotho

This post has two main messages, based on the studies below. Namely, androgens (and especially DHT) potently increase the expression of the anti-aging gene Klotho while estrogens strikingly decrease its expression. Moreover, the more potent the androgen, in terms of androgen receptor (AR) agonism, the more robustly it increases Klotho. Conversely, the most potent the … Read more Androgens boost, estrogen inhibits, anti-aging gene Klotho

Estrogen lowers T, DHT, and fertility; inhibits 5α-Reductase (5-AR)

I am posting this study below as a response to numerous angry emails I have been getting over the years. People sending me those emails just cannot accept the idea that estrogen can be detrimental for males (and females as well), and that estrogen levels are directly antagonistic to the male phenotype. This “‘male antagonism” … Read more Estrogen lowers T, DHT, and fertility; inhibits 5α-Reductase (5-AR)

Aromatase inhibitor (AI) + DHT combo may reverse kidney disease (CKD)

A truly great study for a number of reasons. First, it cites extensive evidence that male patients with diabetes (both types) have low androgens and high estrogen (estradiol). The association between this endocrine abnormality and the severity of diabetes is apparently quite strong, yet it is virtually unknown in endocrinology circles. In fact, there have … Read more Aromatase inhibitor (AI) + DHT combo may reverse kidney disease (CKD)

Topical DHEA has potent anti-aging effects on human skin

I often get emails in regards to possible interventions with anti-aging effects on skin. The study I usually quote is an old one (circa 1967) that did extensive tests on 200+ people with age range of 57-88 years residing in a retirement home, and demonstrated that topical testosterone (1%) cream had the most potent anti-aging … Read more Topical DHEA has potent anti-aging effects on human skin

DHT is negatively associated with death from prostate cancer

Just a quick study that, despite being epidemiological, raises serious questions about the validity of the “androgen-driven” hypothesis of prostate cancer. If the assumption is that DHT is the primary driver of prostate cancer it is hard to come up with any plausible explanation of how the elevated levels of DHT in this study were … Read more DHT is negatively associated with death from prostate cancer

High levels of DHT may reduce diabetes risk

The title says it all, as the study is quite clear. DHT “…was most consistently associated with a lower level of insulin resistance and lower risk of incident diabetes” in the words of the study’s lead author. The current darling of “aging/obese male” treatments – testosterone (T) – was not associated with lower insulin resistance … Read more High levels of DHT may reduce diabetes risk

DHT may be vital for the morphogenesis of organism(s)

As many of my readers know, the potent androgen DHT is one of the most vilified endogenous substances produced by the human body, second only to cholesterol. Aside from verbal vitriol published in mainstream scientific journals, this attitude of medicine towards DHT can also be estimated from the number of prescriptions for 5-alpha-reductase (5-AR) inhibitors … Read more DHT may be vital for the morphogenesis of organism(s)

Lowering DHT synthesis causes severe hypothyroidism, despite higher T levels

Just a quick post in regards to one of the most controversial steroids out there – dihydrotestosterone (DHT). Mainstream medicine has vilified this steroid for decades and has blamed a host of male and female pathologies on it – i.e. baldness, prostate enlragement (BPH), prostate cancer (PC), PCOS, diabetes, obesity, dementia, osteoporosis, etc. One of … Read more Lowering DHT synthesis causes severe hypothyroidism, despite higher T levels

Drop in androgen levels causes Parkinson Disease (PD), DHT reverses it

Yet another study demonstrating that many of the so-called chronic, degenerative and above all “mysterious” conditions often have quite a simple cause and, potentially, treatment. There is no need for mutated genes or complex interactions of genes with environment that nobody can decipher. Chronic stress leads to metabolic and endocrine changes that alone are sufficient … Read more Drop in androgen levels causes Parkinson Disease (PD), DHT reverses it