DHT is negatively associated with death from prostate cancer

Just a quick study that, despite being epidemiological, raises serious questions about the validity of the “androgen-driven” hypothesis of prostate cancer. If the assumption is that DHT is the primary driver of prostate cancer it is hard to come up with any plausible explanation of how the elevated levels of DHT in this study were … Read more DHT is negatively associated with death from prostate cancer

Estrogen and cortisol, not androgens, suppress immunity

There is a very famous theory in reproductive biology still considered the dominant one in its field. Namely, males have to accept a trade-off between androgen levels and immunity. It is known as the immunocompetence handicap hypothesis (ICHH). Higher androgen levels, the theory goes, allow the male to (physically) outcompete other males around him for … Read more Estrogen and cortisol, not androgens, suppress immunity

Drop in androgen levels causes Parkinson Disease (PD), DHT reverses it

Yet another study demonstrating that many of the so-called chronic, degenerative and above all “mysterious” conditions often have quite a simple cause and, potentially, treatment. There is no need for mutated genes or complex interactions of genes with environment that nobody can decipher. Chronic stress leads to metabolic and endocrine changes that alone are sufficient … Read more Drop in androgen levels causes Parkinson Disease (PD), DHT reverses it

Testosterone does NOT impair empathy in men

I am sure most readers are quite familiar with the cliche that testosterone (T) is what drives stereotypical “boy behavior” – aggressiveness, carelessness, impulsive behavior, risk taking, cheating, and of course the militaristic attitude characterized by lack of (or reduced) empathy. As I mentioned in several previous posts, most of these behaviors seem to be … Read more Testosterone does NOT impair empathy in men

Drostanolone (a DHT isomer) may treat prostate cancer

The bad news for the DHT-driven theory of prostate cancer just keep piling on. There have been at least 3 human trials in the last 5 years demonstrating that the direct injection of testosterone (T) into the prostate can stop advanced, inoperable prostate cancer. Instead of admitting what is quite obvious at this point – … Read more Drostanolone (a DHT isomer) may treat prostate cancer