To Extract Knowledge from Matter
Perceive, Think, Act
A gem of a study that throws a wrench in one of medicine’s core dogmas – i.e. androgens have detrimental effects on the immune system and males have evolved to live with a trade-off between high androgen levels (and as such high fertility) and higher risk of severe viral episodes that can be even deadly. … Read more
Despite mentioning it in another post on testosterone (T) treatment for hair loss, I thought that this study deserves its own post, just because its findings are so contradictory to the perennial dogma of “androgenic alopecia” – i.e. that androgens, and especially DHT, cause the male-pattern baldness in males and non-localized hair loss in women. … Read more
The evidence undermining the fake/corrupt hypothesis of “androgenic alopecia” keeps accumulating. I really wish the study below was conducted in men instead of women, since its findings would have probably finally put an end to the debate as to whether androgens promote or inhibit hair growth. However, even in women the findings are quite important … Read more
A great study, a true blast from the (better) past, when androgenic steroids and especially DHT were not considered the devil reincarnate, but were commonly used for all types of ailments, including the broad physiological and psychological symptoms of aging such as sarcopenia (muscle loss), osteoporosis, senility, apathy/depression, and even sexual function. The study demonstrates … Read more
As many of my readers know, back in the “good ol’ days” (when medicine was slightly less evil and berserk) breast cancer in women was treated with androgens, and the results were so impressive that a synthetic DHT-derivative known as Drostanolone / Masteron (2α-Methyl-DHT) was approved by the FDA in 1960s as the main therapy … Read more
A very interesting study that highlights yet again the connection between chronic stress and ill systemic health, especially cardiovascular disease (CVD). The study demonstrates that people who had experienced a heart attack have dramatically higher higher cortisol and adrenaline/noradrenaline levels, combined with low levels of androgens such as testosterone and DHEA a full 6 months … Read more
This post has two main messages, based on the studies below. Namely, androgens (and especially DHT) potently increase the expression of the anti-aging gene Klotho while estrogens strikingly decrease its expression. Moreover, the more potent the androgen, in terms of androgen receptor (AR) agonism, the more robustly it increases Klotho. Conversely, the most potent the … Read more
I did not expect to see this statement in a mainstream science news outlet, but here it is below. I am starting to see a change in attitude towards serotonin but mainstream medicine is careful about its game. Somehow, the message about serotonin has now split into two separate, nonsensical ones – i.e. there are … Read more
A truly great study for a number of reasons. First, it cites extensive evidence that male patients with diabetes (both types) have low androgens and high estrogen (estradiol). The association between this endocrine abnormality and the severity of diabetes is apparently quite strong, yet it is virtually unknown in endocrinology circles. In fact, there have … Read more
I often get emails in regards to possible interventions with anti-aging effects on skin. The study I usually quote is an old one (circa 1967) that did extensive tests on 200+ people with age range of 57-88 years residing in a retirement home, and demonstrated that topical testosterone (1%) cream had the most potent anti-aging … Read more