Alcohol causes liver (and other organ) damage by lowering NAD/NADH ratio

A neat little study, which demonstrates once again the crucial role of energy and optimal redox status in a public health issue that has now reached catastrophic proportions. Namely, alcohol-related morbidity and mortality. Those have always been an issue in any developed country but since the start of the “pandemic” have exacerbated dramatically. As most … Read more

Alcohol brain damage due to iron accumulation; vitamin B1 to the rescue

Chronic alcohol abuse is highly detrimental to health and especially to the brain. Alcohol puts the body in a reductive state and depletes vitamin B1 (thiamine) stores. If the B1 deficiency becomes severe enough it manifests through what is clinically known as Wernicke-Korsakoff syndrome (WKS), characterized by dementia and other severe neurological symptoms. It is … Read more

Blocking serotonin, adrenaline treats anxiety, brain damage due to alcohol “addiction”

Over the last 2 decades a large number of studies have come out demonstrating that the withdrawal symptoms in “addicts” are due largely due to elevated serotonin and adrenaline. As such, drugs such as cyproheptadine, clonidine, propranolol, etc have been successfully used off-label for treating withdrawal symptoms. https://www.ncbi.nlm.nih.gov/pubmed/2178473 https://www.ncbi.nlm.nih.gov/pubmed/6907020 https://link.springer.com/article/10.1007/BF00421401 Now, a new study adds … Read more

Supplementation with (long chain) saturated fats protects liver from alcohol

As many of my readers already know, there are a number of human studies, going back to at least the 1960s, demonstrating that supplementation with saturated fats (SFA) protects the liver from damage induced by alcohol. I fact, supplementation with SFA not only prevents alcohol-induced liver damage but actually fully reverses the fibrosis/cirrhosis induced by … Read more