Low energy production (glucose metabolism) may cause andropause

As many of my readers know, aging men can also experience the equivalent of menopause and doctors informally call that state “andropause”. Its official name is age-related hypogonadism and most of that hypogonadism is of the “secondary” type – i.e. the gonads appears to be in fine shape but for some “unknown” reason they do … Read more Low energy production (glucose metabolism) may cause andropause

The Cure for Aging Might be the Cure for Alzheimer’s

Almost 25 years ago, Dr. Peat himself wrote a 2-article series in which he outlined arguments in favor of the hypothesis that aging and Alzheimer Disease (AD) are just examples of a more and less systemic sign respectively of declining energy production, and that curing one would lead to a cure of the other. http://raypeat.com/articles/articles/alzheimers.shtml … Read more The Cure for Aging Might be the Cure for Alzheimer’s

Policosanol is antiviral and a potent inducer of anti-aging gene Klotho

This post is a good complement to the recent ones I did on androgens, estrogens and their opposing effects on the expression of the anti-aging gene Klotho. While I was doing research on that gene, I had a “random” thought pop up in my mind. It is well-known that some Caribbean countries have a very … Read more Policosanol is antiviral and a potent inducer of anti-aging gene Klotho

Androgens boost, estrogen inhibits, anti-aging gene Klotho

This post has two main messages, based on the studies below. Namely, androgens (and especially DHT) potently increase the expression of the anti-aging gene Klotho while estrogens strikingly decrease its expression. Moreover, the more potent the androgen, in terms of androgen receptor (AR) agonism, the more robustly it increases Klotho. Conversely, the most potent the … Read more Androgens boost, estrogen inhibits, anti-aging gene Klotho

Childhood stress / deprivation leads to early puberty / aging

The evidence that adult health problems have their roots in childhood or even prenatally continues to accumulate. The study below demonstrates that children who have experienced violence, trauma, deprivation or have had generally stressful childhoods not only enter puberty much earlier but are on average several years older (biologically) than their peers. While being several … Read more Childhood stress / deprivation leads to early puberty / aging

Declining vision from aging can be restored by staring at red light

The rates of cataracts, glaucoma, and other vision problems continue to rise and the increasingly aging world population will likely see this problem worsen in the coming years/decades. As such, therapeutic interventions that improve vision are desperately needed. The study below now adds declining vision to the list of problems now known to be caused … Read more Declining vision from aging can be restored by staring at red light

Cardiolipin supplementation may reverse signs of aging

One of the key features of aging is the decline in mitochondrial function (metabolism), and that fact is widely recognized even by mainstream medicine. However, doctors still claim that the relationship between metabolic decline and aging has not be elucidated and a causative link cannot be established (yet). In other words, we don’t know if … Read more Cardiolipin supplementation may reverse signs of aging

Aspirin protects mitochondria from inflammation and aging

The good news about aspirin just never seem to stop. While the anti-inflammatory effects of aspirin are well-known, mainstream medicine like to explain them away with the limited (and frankly primitive) mechanism of COX inhibition alone. If aspirin happens to achieve some other beneficial health effects, the doctors always try to either frame it in … Read more Aspirin protects mitochondria from inflammation and aging

“Anti-aging” hormone (hGH) may actually shorten life

The duo of hGH/IGF-1 does not need an introduction. Hardly a day passes without some ad on TV promoting the latest and greatest product that “naturally boosts” either hGH or IGF-1 levels. The two hormones have an almost perfect correlation – each one inducing the endogenous synthesis of the other. Clinics catering to the super … Read more “Anti-aging” hormone (hGH) may actually shorten life

Striking accumulation of PUFA in aged cells

Peat has written many times about the changes that occur in “aged” cells. Those changes are virtually indistinguishable from the ones that occur in “sick” cells and are characterized by reduced mitochondrial number/size and a shift in lipid composition away from saturated and towards unsaturated fats. The crucial mitochondrial lipid enzyme cardiolipin (CL) comprises at … Read more Striking accumulation of PUFA in aged cells