Negative childhood experiences accelerate aging/disease in humans

I am posting this study mostly as a counterexample to all the drivel coming out of gerontology research circles. Namely, the dogma is that biological aging is overwhelmingly influenced/determined by genes and cannot really be retarded (pun intended) or accelerated by the environment. This dogma persists despite decades of research on pregnant mothers showing maternal … Read more

No evidence for rate-of-living theory of aging

Just a quick post, since this topic dominates anti-aging research – i.e. despite lack of concrete evidence for it, mainstream research (and finding agencies) continue to claim that longevity is tied to metabolism, but in an inverse relationship. The study below is on turtles – one of the longest living organisms on the planet – … Read more

“Endurance” exercise ages the vascular system of males by more than a decade

A very interesting study, though I don’t really agree with its findings that while “endurance” (in this case running) exercise damages male vascular system it is beneficial for the female one. The majority of intervention studies that looked at both sexes, across all age groups found that chronic “endurance” exercise leads to vascular calcification and … Read more

Hypogonadism in older males due to low OXPHOS

I suspect many readers will simply say “duh!”, but believe or not the origin of age-related hypogonadism in males is still considered unknown. Most endocrinologists have discovered experimentally that treating their patients with SERM or AI drugs restores androgens to youthful levels, but the actual cause of this decline in androgens in the first place … Read more

Age-related steroid deficiency may be treatable with niacinamide

The study is actually about eye health, and the effects androgens play in it. However, the findings are not limited to the eyes and are in fact applicable for any other tissue/organ experiencing a decline in steroidogenesis with advancing age, which is basically all of them. As such, I am posting this study not so … Read more

Aging and disease are the same process, driven by low metabolism

I am posting about this mostly due to its “told you so” factor – i.e. more and more professionals in the medical and research fields are starting to realize that the super-specialized approach to treating chronic diseases has not produced any substantial results. In addition, the correlation between age and chronic diseases has pushed scientists … Read more

Exercise brain-boost may be due simply to increasing brain selenium levels

Yet another study demonstrating that many of the “mysterious” benefits of exercise most likely have nothing to do with the (insignificant) amount of extra calories burned, but are due to peripheral effects related to metabolism and redox balance. Namely, the study below investigates the well-known phenomenon that neurogenesis (which declines strongly with age) is strongly … Read more

Fasting causes aging by energy depletion, vitamin B2 can stop it

Well, if this title does not rile up the fasting crowd, I don’t know what will:-) Aside from that controversy, it is actually a great study that not only suggests a dirt cheap and widely available option for retarding aging, but once again demonstrates that stress (e.g. fasting) directly causes aging by depleting/blocking OXPHOS, and … Read more

DHT can stop aging of the pancreatic beta-cells (insulin-producing)

Another great study, which demonstrates that far from being a “villain” (in both males and females) DHT is in fact a crucial and positive factor in health. In this specific study below, it was demonstrated that DHT dose-dependently inhibited the aging/dysfunction of the pancreatic beta-cells, and the highest dose of DHT tested completely stopped that … Read more