Reversing human aging likely possible with progesterone / DHEA

I decided to make a post on this topic after seeing the popular press articles about a study claiming reversal of human biological (as opposed to chronological) aging. That study used human growth hormone (HGH), DHEA and metformin combination as an intervention that restores thymus health and thus reverses immunosenescence (immune system aging). It is … Read more

Supplementation with (long chain) saturated fats protects liver from alcohol

As many of my readers already know, there are a number of human studies, going back to at least the 1960s, demonstrating that supplementation with saturated fats (SFA) protects the liver from damage induced by alcohol. I fact, supplementation with SFA not only prevents alcohol-induced liver damage but actually fully reverses the fibrosis/cirrhosis induced by … Read more

Niacinamide, tetracyclines may prevent / reverse vascular calcification

The study below demonstrates that vascular (and other soft tissue) calficiation depends on overpexression of the enzyme Poly (ADP-ribose) polymerase (PARP). Inhibiting the synthesis/activity of that enzyme prevented vascular calficiation, and as such can be a powerful prevention tool for CVD and in general any ischemic event. The study used minocycline (a tetracycline-family antibiotic) as … Read more

Niacinamide may help treat/reverse heart disease

Yet another study showing the beneficial effects of improving mitochondrial function. This time, the study looked at heart health and found that NAD precursors like niacinamide and nicotinamide riboside (NR) can help prevent the decline in mitochondrial function and oxygen consumption driven by various stresses, including toxic assaults and calcium overload. The study showed that … Read more