Policosanol is antiviral and a potent inducer of anti-aging gene Klotho

This post is a good complement to the recent ones I did on androgens, estrogens and their opposing effects on the expression of the anti-aging gene Klotho. While I was doing research on that gene, I had a “random” thought pop up in my mind. It is well-known that some Caribbean countries have a very … Read more Policosanol is antiviral and a potent inducer of anti-aging gene Klotho

Androgens boost, estrogen inhibits, anti-aging gene Klotho

This post has two main messages, based on the studies below. Namely, androgens (and especially DHT) potently increase the expression of the anti-aging gene Klotho while estrogens strikingly decrease its expression. Moreover, the more potent the androgen, in terms of androgen receptor (AR) agonism, the more robustly it increases Klotho. Conversely, the most potent the … Read more Androgens boost, estrogen inhibits, anti-aging gene Klotho

Estrogen lowers T, DHT, and fertility; inhibits 5α-Reductase (5-AR)

I am posting this study below as a response to numerous angry emails I have been getting over the years. People sending me those emails just cannot accept the idea that estrogen can be detrimental for males (and females as well), and that estrogen levels are directly antagonistic to the male phenotype. This “‘male antagonism” … Read more Estrogen lowers T, DHT, and fertility; inhibits 5α-Reductase (5-AR)

Blocking cortisol may treat even terminal cancers

The metabolic causes of cancer are slowly starting to be recognized, and especially the role of cortisol. I recently did a post on the role of cortisol in triple-negative breast cancer and the protective effects of androgens such as DHT. Now, mainstream medicine does not deny that androgens have therapeutic role in breast cancer (BC) … Read more Blocking cortisol may treat even terminal cancers

PUFA exacerbate, saturated fats (SFA) / albumin / calcium ameliorate COVID-19

A few months ago I posted about a study discussing the role of lipid peroxidation in the COVID-19 pathology. While that study did not make any statements about effects of diet on the disease course/outcome, it did suggest lipid peroxidation blockers such as vitamin E would be therapeutic. Now, we have another study that points … Read more PUFA exacerbate, saturated fats (SFA) / albumin / calcium ameliorate COVID-19

Irritable bowel syndrome (IBS) caused by histamine and serotonin

I did not expect to see this statement in a mainstream science news outlet, but here it is below. I am starting to see a change in attitude towards serotonin but mainstream medicine is careful about its game. Somehow, the message about serotonin has now split into two separate, nonsensical ones – i.e. there are … Read more Irritable bowel syndrome (IBS) caused by histamine and serotonin

Red light therapy for Parkinson Disease (PD) begins human trials

A few weeks ago, I posted about a human study demonstrating reversal of age-related vision decline by staring at a red light for just a few minutes a day. The mechanism of action proposed in that study had to do with improved mitochondrial function and energy production. Now, it seems another branch of medicine – … Read more Red light therapy for Parkinson Disease (PD) begins human trials

Aromatase inhibitor (AI) + DHT combo may reverse kidney disease (CKD)

A truly great study for a number of reasons. First, it cites extensive evidence that male patients with diabetes (both types) have low androgens and high estrogen (estradiol). The association between this endocrine abnormality and the severity of diabetes is apparently quite strong, yet it is virtually unknown in endocrinology circles. In fact, there have … Read more Aromatase inhibitor (AI) + DHT combo may reverse kidney disease (CKD)

Activation of the endotoxin receptor (TLR4) may cause hearing loss

There is currently an epidemic of tinnitus (ear ringing) and hearing loss in virtually all developed countries. Experts are scratching heads and are failing to come up with a reason/explanation for this epidemic. As it often happens, the cause is often hidden in plain sight and if one follows the clues and the available evidence, … Read more Activation of the endotoxin receptor (TLR4) may cause hearing loss

Alcohol brain damage due to iron accumulation; vitamin B1 to the rescue

Chronic alcohol abuse is highly detrimental to health and especially to the brain. Alcohol puts the body in a reductive state and depletes vitamin B1 (thiamine) stores. If the B1 deficiency becomes severe enough it manifests through what is clinically known as Wernicke-Korsakoff syndrome (WKS), characterized by dementia and other severe neurological symptoms. It is … Read more Alcohol brain damage due to iron accumulation; vitamin B1 to the rescue