Niacinamide may treat depression by improving energetic state

A very interesting study, sent to me by a collaborator who lives in Austria. It demonstrated that depression is accompanied by increased SIRT1 activity (i.e. increased fatty acid oxidation), lower ATP levels and redox balance shifted towards reduction. The study demonstrated that animals without the SIRT1 gene were highly resistant to depression and had high … Read more Niacinamide may treat depression by improving energetic state

Sexual activity and stress levels (HPA activity) may determine longevity

The study below tried to tease out the main factors affecting the longevity of the legendary naked mole rat – the animal with longest lifespan in its genus, and the sole mammal known to be virtually immune to developing cancer. Most of the biological/biochemical findings in regards to naked mole rats have already been found … Read more Sexual activity and stress levels (HPA activity) may determine longevity

Aspirin can cure liver cancer in just 24 hours (in rabbits)

A pair of studies by a group of scientists in Brazil. They used intratumoral injections of a 5% aspirin or 5% acetic acid (vinegar) solution in the first study, and 10% solutions of each in the second study. EITHER treatment not only destroyed the tumor within 24 hours but after 7 days all the biochemical … Read more Aspirin can cure liver cancer in just 24 hours (in rabbits)

Glycine (and leucine) can treat fatty liver (NAFLD and NASH)

A great new study that demonstrates the strong protective effects of glycine, alone or in combination with leucine, on preventing/treating various forms of fatty liver disease, as well as the obesity that often accompanies these conditions. One of the strong points of the study is that it also established a minimum daily dosage needed to … Read more Glycine (and leucine) can treat fatty liver (NAFLD and NASH)

Serotonin promotes (futile) patience and (false) faith in future rewards

This study alone explains so much of the pathological behavior seen in humans living in developed countries. Namely, the vast majority of them are willing to break their backs working and “delaying gratification” in the hopes that one day they will “make it” and all of their efforts will be generously rewarded. Of course, this … Read more Serotonin promotes (futile) patience and (false) faith in future rewards

Serotonin (and SSRI drugs) can cause anxiety and PTSD

Yet another great study exposing just how much of a “happy hormone” serotonin really is. As usual, the popular press article does everything possible to avoid pointing the finger at serotonin and even engages in misdirection. For example, it says that SERT is the main target of drugs like cocaine, while in reality it is … Read more Serotonin (and SSRI drugs) can cause anxiety and PTSD

Progesterone and allpregnanolone are protective against COVID-19

I think we will be seeing more studies on this topic, especially in light of the ongoing human studies administering progesterone or (gasp!) estrogen to men in the hopes of improving the course of their COVID-19 disease. The results from the estrogen trials are already – surprise, surprise – strongly negative, and the progesterone trials … Read more Progesterone and allpregnanolone are protective against COVID-19

Oral pregnenolone as hormone replacement therapy (HRT) in humans

As many of my readers know, the first step in steroid synthesis is the so-called “side-chain cleavage”, which converts cholesterol into pregnenolone (P5). That step is known as the rate-limiting step in the steroid cascade, and its function depends on the redox status and ATP levels. In other words, the rate-limiting step of steroid synthesis … Read more Oral pregnenolone as hormone replacement therapy (HRT) in humans

Compared to meat eaters, vegans / vegetarian / pescatarians have higher risk of fractures

The study just hit major news outlets and is generating a lot of “controversy”. Why putting that word in quotes? Because, as I mentioned in several other posts, that word has become a euphemism for “embarrassing truth” that mainstream medicine (and often society at large) will do just about anything to suppress. While the negative … Read more Compared to meat eaters, vegans / vegetarian / pescatarians have higher risk of fractures

Orange juice (OJ) as therapy for all coronaviruses, including SARS-CoV-2

If anybody needs a reason to convince themselves (or their family members) that drinking OJ is beneficial, maybe this new study in the context of COVID-19 will be good enough as evidence. It demonstrated that one of the main components of OJ – naringenin – is a powerful inhibitor of viral replication and it also … Read more Orange juice (OJ) as therapy for all coronaviruses, including SARS-CoV-2