Endotoxin (LPS) causes rheumatoid arthritis…and COVID-19

A great new study, which is perhaps the first to directly point the finger at endotoxin as perhaps the main cause of rheumatoid arthritis (RA). RA is an “autoimmune” condition and not only shares symptoms with other similar conditions such as Lupus, psoriasis, MS, etc, but now all of them are considered officially to be … Read more

Endotoxin (LPS) as a cause of liver disease, obesity and diabetes

The first article below is actually about praising fermented foods, which I don’t really agree with. So, I am posting it mostly because of the quote on endotoxin/LPS, which is a very rare finding in published medical literature since medicine does not recognize chronic, low-grade endotoxemia as a cause of any disease and claims the … Read more

Blocking the endotoxin receptor (TLR4) may prevent / treat hearing loss

I did a post a few months ago on the connection between tinnitus and serotonin – i.e. using anti-serotonin drugs may treat tinnitus. Since tinnitus is almost always a precursor state to hearing loss (and eventually deafness), the two conditions obviously go hand-in-hand and are likely caused by the same agent (e.g. serotonin). Since more … Read more

Endotoxin (LPS) may be the cause of fatal lung damage in COVID-19

Yet another study, which demonstrates that there is virtually no disease (acute of chronic, infections or not) where the infamous LPS does not play a causative role. As it turns out, the often fatal inflammatory reaction (cytokine storm) that usually kills patients with COVID-19 in ICU, is driven by endotoxin through activation of its TLR4 … Read more

Silica, present in most supplements/food, activates the endotoxin receptor (TLR4)

Many of my readers know about the health risks of silica – a substance doctors and pundits call completely “benign, present in virtually all commercially sold dietary supplements and also in most commercially sold food (even organic ones!). The most commonly used form commercially is silicon dioxide, which is essentially powdered glass! However, despite its … Read more

Endotoxin (LPS) as a cause of systemic inflammation seen in obesity

Yet another study implicating the great villain of systemic health – endotoxin / LPS. It is well-known that most people with obesity have high levels of inflammatory biomarkers both in their tissues and bloodstream. The study below demonstrates that the inflammation seen in adipose tissue of obese organisms is likely due to endotoxin / LPS. … Read more

Activation of the endotoxin receptor (TLR4) may cause hearing loss

There is currently an epidemic of tinnitus (ear ringing) and hearing loss in virtually all developed countries. Experts are scratching heads and are failing to come up with a reason/explanation for this epidemic. As it often happens, the cause is often hidden in plain sight and if one follows the clues and the available evidence, … Read more

Pregnenolone safe and effective in big human trial for back pain

About 2 years ago I posted about a study that suggested pregnenolone may relieve low-back pain in humans. At the time, a bigger human clinical trial was planned and the results of that trial were just released. Pregnenolone, slowly titrated to reach doses of 500mg/day, was found to be safe and effective for low-back pain … Read more

Asthma is driven by endotoxin and its receptors (TLR4, TLR5)

Yet another study demonstrating the crucial role of the endotoxin/LPS (and its sentinel receptors) in a chronic idiopathic condition – in this case asthma. The cause of asthma is, as usual, officially claimed to be unknown but it is known that asthma can be exacerbated by environmental pollution (even though a causal relationship is flatly … Read more

Epilepsy, as a result of brain injury (TBI), is caused by endotoxin receptor (TLR4)

Traumatic brain injury (TBI) is a pathology affecting most often military staff exposed to explosions, competitive athletes in contact sports (especially in the NFL), accident victims, etc but lately has also been shown to occur in more benign situations such as repeated low-grade impacts such as playing soccer on a regular basis and heading the … Read more