Endotoxin has a G.E.L.D.I.N.G effect, causes obesity and hypogonadism

A very interesting study proposing that the decline in gonadal function seen in obese/diabetic men is due to chronically elevated endotoxin levels in such people. The study calls this phenomenon (G)ut (E)dotoxin (L)eading to a (D)ecline (I)n (G)onadal function (GELDING) due to the remarkable similarities in the phenotypes caused by castration and chronic endotoxemia. While … Read more Endotoxin has a G.E.L.D.I.N.G effect, causes obesity and hypogonadism

Allopregnanolone as a treatment of Alzheimer Disease (AD)

It looks like the recent FDA approval of allopregnanolone (ALLO) for postpartum depression may open the floodgates to ton of new research with this steroid, as well as with its reliable precursors such as pregnenolone and progesterone. I posted several studies in the past demonstrating that pregnenolone, progesterone and ALLO are all endotoxin antagonists and … Read more Allopregnanolone as a treatment of Alzheimer Disease (AD)

Chronic nerve pain may be caused by endotoxin, commercial food, and pharma drugs

I posted a few threads last year demonstrating that some cases of chronic nerve pain may be caused by a side effects of opioids – activation of TLR4. However, that study only looked at why certain patients using opioids for severe pain go on to develop chronic pain of phantom origin. As such, the study … Read more Chronic nerve pain may be caused by endotoxin, commercial food, and pharma drugs

Inhibiting fatty acid synthesis (FAS) dramatically improves sepsis survival rate

Yet another study that points the finger straight at fat as a key factor in one of the most common causes of inpatient hospital mortality – sepsis. Sepsis is currently considered to be a condition of infectious (bacterial) etiology, driven by endotoxin. However, in light of the new findings it may be more appropriate to … Read more Inhibiting fatty acid synthesis (FAS) dramatically improves sepsis survival rate

Progesterone may bind and deactivate endotoxin (LPS) directly

I made a few posts recently discussing the blocking effects of pregnenolone on TLR4 and TLR family receptors in general, and the reduction of systemic inflammation stemming from this blockade/regulation. http://haidut.me/?p=17 It is well-known that glucocorticoids and mineralocorticoids are protective against endotoxemic shock, possibly due to blocking the hypotensive and inflammatory effects of endotoxin. However, … Read more Progesterone may bind and deactivate endotoxin (LPS) directly

MS Tied To Glucose Deficiency Due To Endotoxin And Fat, Extra Glucose May Treat It

Just a few days ago I posted the groundbreaking study on metabolic derangement in ALS – i.e. it is a diseased characterized by increased FAO, which wastes glucose. Simply increasing dietary glucose was able to greatly restrain the pathology. Well, hot on the heels of that study is the study below, which found very similar … Read more MS Tied To Glucose Deficiency Due To Endotoxin And Fat, Extra Glucose May Treat It

Elevated endotoxin (LPS) linked to lower survival in cancer

Another study about endotoxin, this time linking higher sensitivity to endotoxin to lower survival chance for people with lymphoma. While the study below looked at only one cancer, there are multiple studies with other cancer that have found a similar link. Endotoxin and cancer go hand in hand, that much is clear. https://www.dovepress.com/tlr4-expression-correlated-with-pd-l1-expression-indicates-a-poor-prog-peer-reviewed-article-CMAR “…Background: Toll-like … Read more Elevated endotoxin (LPS) linked to lower survival in cancer

Blocking endotoxin (LPS) may reverse/cure diabetes type I (insulin dependent)

Yet another study demonstrating the key role of endotoxin in the pathology of perhaps the most widespread chronic disease – diabetes. The study below discovered that the proliferation of the insulin-producing beta-cells in the pancreas is controlled almost entirely by the TLR4/TLR2 receptor family. Activation of those receptors led to rapid death of beta-cells and, … Read more Blocking endotoxin (LPS) may reverse/cure diabetes type I (insulin dependent)

Endotoxin (LPS) may cause depression / anhedonia

As many readers know, anhedonia is one of the most pernicious aspects of clinical depression. It is present in other mental health conditions but is most pronounced and severe in clinical unipolar depression. It is also especially resistant to treatment and many doctors simply accept it as something that current drugs cannot address and focus … Read more Endotoxin (LPS) may cause depression / anhedonia