Vitamin D3 anabolic, calcitriol catabolic for muscle/thymus

Several great studies, which will probably do little to calm down the controversy that seems to be brewing lately in the blogosphere over whether supplementing with vitamin D3 is beneficial or not. Namely, the last study below demonstrated direct muscle-anabolic effects from supplementation with vitamin D3 (cholecalciferol), in direct opposition to the known catabolic effects … Read more

Glucose is anabolic for thymus, opposes catabolic effects of cortisol

As most of my readers know, cortisol is a highly catabolic steroid and one of the main agents (estrogen being another) responsible for thymus atrophy with age. These catabolic effects of cortisol can be blocked by progesterone, DHEA, pregnenolone and even DHT (but not by testosterone). The study below confirms the catabolic effects of cortisol … Read more

Estrogen and cortisol, not androgens, suppress immunity

There is a very famous theory in reproductive biology still considered the dominant one in its field. Namely, males have to accept a trade-off between androgen levels and immunity. It is known as the immunocompetence handicap hypothesis (ICHH). Higher androgen levels, the theory goes, allow the male to (physically) outcompete other males around him for … Read more

Reversing human aging likely possible with progesterone / DHEA

I decided to make a post on this topic after seeing the popular press articles about a study claiming reversal of human biological (as opposed to chronological) aging. That study used human growth hormone (HGH), DHEA and metformin combination as an intervention that restores thymus health and thus reverses immunosenescence (immune system aging). It is … Read more