Lab animals kept under stressful conditions, thus affecting study results

Several months ago, I did a post on just how stressful the IP administration method is for lab animals. That method is considered the de-facto standard for steroid studies, yet it appears it is so stressful that it can easily produce invalid results due to the its strong effects on the HPA axis and overall … Read more

Studies in animals often use stressful methods that produce invalid results

Back in 2012, when I first started writing about the benefits of steroids such as pregnenolone, I often got emails quoting the study below as evidence that pregnenolone and related steroids amplify instead of mitigate the stress response (HPA axis). https://www.ncbi.nlm.nih.gov/pubmed/17928160 “…We chose IP injection to assess neuroactive steroids effects at the central level because … Read more

FDA and NIH let clinical trial sponsors keep results secret (illegally)

A very good overview of how little power (or incentive) the federal authorities have to ensure proper reporting of clinical trials results, considering their own trials/studies are some of the biggest violators. By law, all sponsored human research/trial has to be registered in the public database ClinicalTrials.gov and upon completion its results should also be … Read more