Lipolysis / FFA drive breast cancer by promoting estrogen signalling

The evidence for the fat-loving nature of cancer just keeps on accumulating. During the last podcast with Danny and Ray, I mentioned that in cancer cells the enzyme fatty acid synthase (FAS) is actually part of the estrogen receptor (ER) complex. As such, anything that increases the expression/activity of one promotes the other as well. … Read more Lipolysis / FFA drive breast cancer by promoting estrogen signalling

Increased fatty acid synthesis (FAS) is simply a sign of oxygen deficiency / low metabolism

Just a quick post on a study that provides insight as to how increased fatty acid oxidation (FAO) can “paradoxically” result in increased FAS as well, thus leading to a vicious cycle most commonly seen in diabetes and cancer. One of my recent posts discussed a much more recent study that demonstrated the same effect … Read more Increased fatty acid synthesis (FAS) is simply a sign of oxygen deficiency / low metabolism

Acidosis (Warburg Effect) drives cancer through increased fat oxidation (Randle Cycle)

The evidence continues to pile on that naming the (in)famous observation made by Otto Warburg in regards to cancer an “effect” is one of the most profound falsehoods the medical profession has ever concocted. Almost a century after the Warburg “Effect” term was coined, the evidence rapidly accumulates that the lactic acidosis is not at … Read more Acidosis (Warburg Effect) drives cancer through increased fat oxidation (Randle Cycle)

Inhibiting fatty acid synthesis (FAS) dramatically improves sepsis survival rate

Yet another study that points the finger straight at fat as a key factor in one of the most common causes of inpatient hospital mortality – sepsis. Sepsis is currently considered to be a condition of infectious (bacterial) etiology, driven by endotoxin. However, in light of the new findings it may be more appropriate to … Read more Inhibiting fatty acid synthesis (FAS) dramatically improves sepsis survival rate

MS Tied To Glucose Deficiency Due To Endotoxin And Fat, Extra Glucose May Treat It

Just a few days ago I posted the groundbreaking study on metabolic derangement in ALS – i.e. it is a diseased characterized by increased FAO, which wastes glucose. Simply increasing dietary glucose was able to greatly restrain the pathology. Well, hot on the heels of that study is the study below, which found very similar … Read more MS Tied To Glucose Deficiency Due To Endotoxin And Fat, Extra Glucose May Treat It

Increased fat oxidation (FAO) does not lead to weight/fat loss

The study below directly contradicts a mantra commonly repeated in nutrition circles – restrict glucose and increase fat oxidation in order to lose weight, and more specifically body fat. In fact, this idea is so ingrained into the minds of most people that I often get hate mail from people all over the world angrily … Read more Increased fat oxidation (FAO) does not lead to weight/fat loss