Almost 40% of military women (and even more military males) are infertile

I think this study should dispel some of the myths about what being “fit” really means, and that being truly healthy or “fit” often are quite divergent paths. Infertility is actually one of the most reliable indicators of poor systemic health and predictor of future chronic disease (in both sexes). So, by that measure, almost … Read more Almost 40% of military women (and even more military males) are infertile

Progesterone may treat diabetes, obesity, and metabolic syndrome

Interesting new study, which adds more to the already existing mountain of evidence for the benefit of progesterone in a variety of conditions of metabolic origin. While the study does not mention any specific doses, it is known that the receptor (PGRMC2) whose activation the study found to be beneficial for diabetes/obesity, is activated by … Read more Progesterone may treat diabetes, obesity, and metabolic syndrome

Inhibiting estrogen synthesis may treat / prevent ectopic pregnancy

I just made a post about the role of estrogen in male infertility, which matches perfectly the evidence about estrogen’s role as a metabolic inhibitor, and an agent that causes atrophy in both male and female gonads. Male fertility depends on intensity of (sperm) metabolism Now, a new study demonstrates that using an aromatase inhibitor … Read more Inhibiting estrogen synthesis may treat / prevent ectopic pregnancy

Male fertility depends on intensity of (sperm) metabolism

Yet another aspect of health that turns out to be directly controlled by quality/speed of metabolism. I made a few posts in the past demonstrating that progesterone and pregnenolone activate a calcium channel (CatSper) specific to progesterone, which greatly increases sperm motility. https://www.nature.com/articles/nature09767 https://www.sciencedaily.com/releases/2016/03/160317150803.htmhttps://www.sciencedaily.com/releases/2016/03/160317150803.htm However, I suspected that this is not the whole story behind … Read more Male fertility depends on intensity of (sperm) metabolism

Estrogen, not HPV, causes cervical cancer; progesterone can stop / reverse it

Yet another one of the carefully crafted, fear mongering myths that modern medicine literally sells to us on a daily basis just got busted. As many of my readers know, there has been huge publicity over the last 10 years in regards to the human papillomavirus (HPV) and the multitude of cancers is purportedly causes. … Read more Estrogen, not HPV, causes cervical cancer; progesterone can stop / reverse it

Estrogen and cortisol, not androgens, suppress immunity

There is a very famous theory in reproductive biology still considered the dominant one in its field. Namely, males have to accept a trade-off between androgen levels and immunity. It is known as the immunocompetence handicap hypothesis (ICHH). Higher androgen levels, the theory goes, allow the male to (physically) outcompete other males around him for … Read more Estrogen and cortisol, not androgens, suppress immunity

Humans have a ‘salamander-like’ ability to regrow cartilage

The title says it all, but the study authors make the unfortunate/handicapped conclusion that while we may very well be able to regrow cartilage, we cannot regrow limbs. Well, multiple animal studies I posted in the last beg to disagree and point to both high metabolism and progesterone as potent regenerative factors that may be … Read more Humans have a ‘salamander-like’ ability to regrow cartilage

Natural progesterone (but not synthetic progestins) has potent anti-hypertensive effects

As many readers already know, synthetic estrogens and progestins currently dominate the market for female reproductive health. These chemicals are in everything from birth control pills, to drugs for “treating” endometriosis, to drugs for menopausal symptoms, to treating neurodegenerative diseases such as Alzheimer’s, etc. The argument for using synthetic version of both hormones has always … Read more Natural progesterone (but not synthetic progestins) has potent anti-hypertensive effects

Reversing human aging likely possible with progesterone / DHEA

I decided to make a post on this topic after seeing the popular press articles about a study claiming reversal of human biological (as opposed to chronological) aging. That study used human growth hormone (HGH), DHEA and metformin combination as an intervention that restores thymus health and thus reverses immunosenescence (immune system aging). It is … Read more Reversing human aging likely possible with progesterone / DHEA

Allopregnanolone as a treatment of Alzheimer Disease (AD)

It looks like the recent FDA approval of allopregnanolone (ALLO) for postpartum depression may open the floodgates to ton of new research with this steroid, as well as with its reliable precursors such as pregnenolone and progesterone. I posted several studies in the past demonstrating that pregnenolone, progesterone and ALLO are all endotoxin antagonists and … Read more Allopregnanolone as a treatment of Alzheimer Disease (AD)