Blocking cortisol may treat even terminal cancers

The metabolic causes of cancer are slowly starting to be recognized, and especially the role of cortisol. I recently did a post on the role of cortisol in triple-negative breast cancer and the protective effects of androgens such as DHT. Now, mainstream medicine does not deny that androgens have therapeutic role in breast cancer (BC) … Read more Blocking cortisol may treat even terminal cancers

Progesterone – not a sex hormone, but a systemic health hormone

An older study, but some great information in there. Not only does it call attention to the fallacy of progesterone being nothing more than a “sex” hormone, but it also warns about the fallacy of equating the synthetic progestins with bioidentical progesterone. At least, when it comes to vascular/heart/muscle effects. Over the last 15 years … Read more Progesterone – not a sex hormone, but a systemic health hormone

Topical DHEA has potent anti-aging effects on human skin

I often get emails in regards to possible interventions with anti-aging effects on skin. The study I usually quote is an old one (circa 1967) that did extensive tests on 200+ people with age range of 57-88 years residing in a retirement home, and demonstrated that topical testosterone (1%) cream had the most potent anti-aging … Read more Topical DHEA has potent anti-aging effects on human skin

Almost 40% of military women (and even more military males) are infertile

I think this study should dispel some of the myths about what being “fit” really means, and that being truly healthy or “fit” often are quite divergent paths. Infertility is actually one of the most reliable indicators of poor systemic health and predictor of future chronic disease (in both sexes). So, by that measure, almost … Read more Almost 40% of military women (and even more military males) are infertile

Progesterone may treat diabetes, obesity, and metabolic syndrome

Interesting new study, which adds more to the already existing mountain of evidence for the benefit of progesterone in a variety of conditions of metabolic origin. While the study does not mention any specific doses, it is known that the receptor (PGRMC2) whose activation the study found to be beneficial for diabetes/obesity, is activated by … Read more Progesterone may treat diabetes, obesity, and metabolic syndrome

Inhibiting estrogen synthesis may treat / prevent ectopic pregnancy

I just made a post about the role of estrogen in male infertility, which matches perfectly the evidence about estrogen’s role as a metabolic inhibitor, and an agent that causes atrophy in both male and female gonads. Male fertility depends on intensity of (sperm) metabolism Now, a new study demonstrates that using an aromatase inhibitor … Read more Inhibiting estrogen synthesis may treat / prevent ectopic pregnancy

Male fertility depends on intensity of (sperm) metabolism

Yet another aspect of health that turns out to be directly controlled by quality/speed of metabolism. I made a few posts in the past demonstrating that progesterone and pregnenolone activate a calcium channel (CatSper) specific to progesterone, which greatly increases sperm motility. https://www.nature.com/articles/nature09767 https://www.sciencedaily.com/releases/2016/03/160317150803.htmhttps://www.sciencedaily.com/releases/2016/03/160317150803.htm However, I suspected that this is not the whole story behind … Read more Male fertility depends on intensity of (sperm) metabolism

Estrogen, not HPV, causes cervical cancer; progesterone can stop / reverse it

Yet another one of the carefully crafted, fear mongering myths that modern medicine literally sells to us on a daily basis just got busted. As many of my readers know, there has been huge publicity over the last 10 years in regards to the human papillomavirus (HPV) and the multitude of cancers is purportedly causes. … Read more Estrogen, not HPV, causes cervical cancer; progesterone can stop / reverse it

Estrogen and cortisol, not androgens, suppress immunity

There is a very famous theory in reproductive biology still considered the dominant one in its field. Namely, males have to accept a trade-off between androgen levels and immunity. It is known as the immunocompetence handicap hypothesis (ICHH). Higher androgen levels, the theory goes, allow the male to (physically) outcompete other males around him for … Read more Estrogen and cortisol, not androgens, suppress immunity

Humans have a ‘salamander-like’ ability to regrow cartilage

The title says it all, but the study authors make the unfortunate/handicapped conclusion that while we may very well be able to regrow cartilage, we cannot regrow limbs. Well, multiple animal studies I posted in the last beg to disagree and point to both high metabolism and progesterone as potent regenerative factors that may be … Read more Humans have a ‘salamander-like’ ability to regrow cartilage