Blocking cortisol may treat terminal pancreatic cancer

Recently, I made a post about some truly amazing results in treating terminal cancer patients with the glucocorticoid/progesterone antagonist Mifepristone (RU486). Some of the cases were stage 4 and possibly terminal. Now, a new case study below reports possibly curative effects on a confirmed terminal case of pancreatic cancer using 200mg daily dose of RU486. … Read more

Stress (cortisol) causes pre-term birth by blocking progesterone

If you ask a gynecologist what causes premature birth, the answer will usually be something along the lines of “insufficient progesterone” often accompanied by mumbling about “genetic predispositions”. Yet, how exactly is insufficient progesterone responsible for premature birth has remained a mystery, at least for most practicing doctors. Back in the first half of the … Read more

DHT / Progesterone / aspirin treat, cortisol ineffective, PUFA promotes prostate cancer

A great study, albeit in-vitro, that once again throws into doubt the entire hypothesis behind prostate cancer. First, it proves the key role of PUFA in the genesis and progression of prostate cancer by demonstrating that inhibitors of the COX enzyme (responsible for synthesizing prostaglandins from PUFA) are therapeutic even when used as a monotherapy. … Read more

Progesterone and allpregnanolone are protective against COVID-19

I think we will be seeing more studies on this topic, especially in light of the ongoing human studies administering progesterone or (gasp!) estrogen to men in the hopes of improving the course of their COVID-19 disease. The results from the estrogen trials are already – surprise, surprise – strongly negative, and the progesterone trials … Read more

Blocking cortisol may treat even terminal cancers

The metabolic causes of cancer are slowly starting to be recognized, and especially the role of cortisol. I recently did a post on the role of cortisol in triple-negative breast cancer and the protective effects of androgens such as DHT. Now, mainstream medicine does not deny that androgens have therapeutic role in breast cancer (BC) … Read more

Progesterone – not a sex hormone, but a systemic health hormone

An older study, but some great information in there. Not only does it call attention to the fallacy of progesterone being nothing more than a “sex” hormone, but it also warns about the fallacy of equating the synthetic progestins with bioidentical progesterone. At least, when it comes to vascular/heart/muscle effects. Over the last 15 years … Read more

Topical DHEA has potent anti-aging effects on human skin

I often get emails in regards to possible interventions with anti-aging effects on skin. The study I usually quote is an old one (circa 1967) that did extensive tests on 200+ people with age range of 57-88 years residing in a retirement home, and demonstrated that topical testosterone (1%) cream had the most potent anti-aging … Read more

Almost 40% of military women (and even more military males) are infertile

I think this study should dispel some of the myths about what being “fit” really means, and that being truly healthy or “fit” often are quite divergent paths. Infertility is actually one of the most reliable indicators of poor systemic health and predictor of future chronic disease (in both sexes). So, by that measure, almost … Read more

Progesterone may treat diabetes, obesity, and metabolic syndrome

Interesting new study, which adds more to the already existing mountain of evidence for the benefit of progesterone in a variety of conditions of metabolic origin. While the study does not mention any specific doses, it is known that the receptor (PGRMC2) whose activation the study found to be beneficial for diabetes/obesity, is activated by … Read more

Inhibiting estrogen synthesis may treat / prevent ectopic pregnancy

I just made a post about the role of estrogen in male infertility, which matches perfectly the evidence about estrogen’s role as a metabolic inhibitor, and an agent that causes atrophy in both male and female gonads. Male fertility depends on intensity of (sperm) metabolism Now, a new study demonstrates that using an aromatase inhibitor … Read more