Higher progesterone, lower estrogen makes women more generous

It looks like the beneficial effects if progesterone and harmful effects of estrogen are not limited to health. The study below found a women become much more generous in terms of buying drinks or gifts for their peers during the luteal phase, when progesterone is elevated and estrogen is low. If progesterone and estrogen are … Read more

Ocular progesterone administration may treat eye, brain, and mental illness

A few months ago, I posted a study demonstrating improvement in localized, ocular steroidogenesis by administration of a small amount of niacinamide (as an aqueous solution) directly into the eye. It looks like ocular administration of a variety of substances is a hot topic in research circles, as I saw a number of other studies … Read more

Estrogen may cause/exacerbate reflux disease (GERD)

A very interesting study, which once again corroborates the hypothesis that there is no chronic condition, which is not either caused or heavily influenced by steroids. Among the conditions medicine considers not to be linked to hormone imbalances is the extremely common “reflux disease”, medically known as GERD. The official dogma is that GERD is … Read more

Alzheimer’s Severity Tied to Longer Estrogen Exposure in Women

A neat study, which somehow managed to slip through my “radar” when it was first published the middle of last (2021) year. The study is pretty straighforward in its claim that longer exposure to endogenous estrogen was associated with exacerbated/higher biomarkers of Alzheimer disease (AD), as well as lower glucose metabolism and smaller brain volume … Read more

Estrogen promotes, progesterone inhibits drug (cocaine) abuse

An interesting study, which not only exposes yet another negative side of estrogen but also demonstrates the opposing actions estrogen and progesterone have on the brain. The former is excitatory (by activating the glutamate system and inhibiting the GABA system) while the latter does the exact opposite (acts as a glutamate antagonist and GABA agonist). … Read more

Stress causes/exacerbates allergies, pregnenolone/progesterone therapeutic

Yet another studies demonstrating the “controversial” link between stress and a condition doctors insist has nothing to do with stress or hormones in general. This time the culprit is CRF/CRH, which is the initial step in the “stress” cascade and is now known to be implicated in conditions such as multiple sclerosis (MS), Alzheimer, depression … Read more

Endocrine disruptors in cosmetics may cause postpartum depression, premature births

Hardly a surprising finding, but it will probably come as a shock to most modern women who are the biggest consumers of such products (e.g. nail polish, perfumes, shampoo, etc). One of the reasons for this “controversy” is that doctors continue to insist that using such products during pregnancy is perfectly safe, for both mom-to-be … Read more

Blocking cortisol may treat terminal pancreatic cancer

Recently, I made a post about some truly amazing results in treating terminal cancer patients with the glucocorticoid/progesterone antagonist Mifepristone (RU486). Some of the cases were stage 4 and possibly terminal. Now, a new case study below reports possibly curative effects on a confirmed terminal case of pancreatic cancer using 200mg daily dose of RU486. … Read more

Stress (cortisol) causes pre-term birth by blocking progesterone

If you ask a gynecologist what causes premature birth, the answer will usually be something along the lines of “insufficient progesterone” often accompanied by mumbling about “genetic predispositions”. Yet, how exactly is insufficient progesterone responsible for premature birth has remained a mystery, at least for most practicing doctors. Back in the first half of the … Read more

DHT / Progesterone / aspirin treat, cortisol ineffective, PUFA promotes prostate cancer

A great study, albeit in-vitro, that once again throws into doubt the entire hypothesis behind prostate cancer. First, it proves the key role of PUFA in the genesis and progression of prostate cancer by demonstrating that inhibitors of the COX enzyme (responsible for synthesizing prostaglandins from PUFA) are therapeutic even when used as a monotherapy. … Read more